Detailed information NTG1116614

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: EW025_RS03735
• Genome accession: NZ_LR130238
• Coordinates: 716149..717378 (+)
• Length: 409 a.a.
• NCBI ID: WP_002984948.1
• Uniprot ID: A0A4U7GJW1
• Organism: Streptococcus pyogenes strain HKU419 isolate HKU419
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 711149..722378

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW025_RS03710	-	711765..713042 (-)	1278	WP_010922170.1	hydroxymethylglutaryl-CoA reductase, degradative	-
EW025_RS03715	-	713029..714204 (-)	1176	WP_010922171.1	hydroxymethylglutaryl-CoA synthase	-
EW025_RS03720	-	714413..715252 (+)	840	WP_010922172.1	thymidylate synthase	-
EW025_RS03725	-	715332..715829 (+)	498	WP_011285487.1	dihydrofolate reductase	-
EW025_RS03730	-	715849..716019 (+)	171	WP_002984950.1	hypothetical protein	-
EW025_RS03735	clpX	716149..717378 (+)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
EW025_RS03740	yihA	717388..717987 (+)	600	WP_002984945.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
EW025_RS03745	-	718135..718878 (+)	744	WP_002984942.1	hypothetical protein	-
EW025_RS03750	-	718936..721035 (-)	2100	WP_010922175.1	AAA family ATPase	-
EW025_RS03755	rpiA	721414..722097 (+)	684	WP_010922176.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 44991.44 Da
• Isoelectric Point: 4.5775

>NTDB_id=1116614 EW025_RS03735 WP_002984948.1 716149..717378(+) (clpX) [Streptococcus pyogenes strain HKU419 isolate HKU419]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=1116614 EW025_RS03735 WP_002984948.1 716149..717378(+) (clpX) [Streptococcus pyogenes strain HKU419 isolate HKU419]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

3D structure

• AlphaFold DB: A0A4U7GJW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575