Detailed information NTG1116296

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQB42_RS09615
• Genome accession: NZ_LR129841
• Coordinates: 1820804..1821841 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727278.1
• Uniprot ID: A0A4J2BD57
• Organism: Streptococcus pneumoniae strain 947 isolate 947
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1815804..1826841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQB42_RS09590	-	1816543..1817874 (-)	1332	WP_000390043.1	hemolysin family protein	-
EQB42_RS09595	endA	1818165..1818989 (-)	825	WP_001036789.1	DNA-entry nuclease EndA	Machinery gene
EQB42_RS09600	-	1819028..1819216 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
EQB42_RS09605	murA	1819209..1820492 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQB42_RS09610	-	1820516..1820746 (-)	231	WP_000250392.1	DUF1146 family protein	-
EQB42_RS09615	sepM	1820804..1821841 (-)	1038	WP_000727278.1	SepM family pheromone-processing serine protease	Regulator
EQB42_RS09620	coaD	1821825..1822313 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
EQB42_RS09625	rsmD	1822303..1822842 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQB42_RS09630	asnA	1822907..1823899 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQB42_RS09640	-	1824012..1824695 (-)	684	WP_001016913.1	Bax inhibitor-1 family protein	-
EQB42_RS09645	-	1824751..1825491 (-)	741	WP_000152698.1	TrmH family RNA methyltransferase	-
EQB42_RS09650	-	1825525..1825803 (+)	279	WP_001174612.1	acylphosphatase	-
EQB42_RS09655	yidC	1825881..1826807 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37510.55 Da
• Isoelectric Point: 5.0724

>NTDB_id=1116296 EQB42_RS09615 WP_000727278.1 1820804..1821841(-) (sepM) [Streptococcus pneumoniae strain 947 isolate 947]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNSP

Nucleotide

• Length: 1038 bp

>NTDB_id=1116296 EQB42_RS09615 WP_000727278.1 1820804..1821841(-) (sepM) [Streptococcus pneumoniae strain 947 isolate 947]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAGTCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A4J2BD57

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60	98.551	0.591