Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   E0E09_RS00325 Genome accession   NZ_LR027869
Coordinates   64993..66339 (-) Length   448 a.a.
NCBI ID   WP_000816499.1    Uniprot ID   Q9R3W9
Organism   Staphylococcus aureus isolate BPH2869     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 45180..66339 64993..66339 within 0


Gene organization within MGE regions


Location: 45180..66339
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0E09_RS00215 mecA 45180..47189 (-) 2010 WP_078065777.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  E0E09_RS00220 mecR1 47286..49043 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  E0E09_RS00225 mecI 49043..49414 (+) 372 WP_000369216.1 mecA-type methicillin resistance repressor MecI -
  E0E09_RS00230 psm-mec 49499..49567 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  E0E09_RS00235 - 49901..51031 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  E0E09_RS00240 cstB 51145..52479 (-) 1335 Protein_41 persulfide dioxygenase-sulfurtransferase CstB -
  E0E09_RS00245 - 52512..53576 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  E0E09_RS00250 cstR 53712..53972 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  E0E09_RS00255 - 53972..54610 (+) 639 Protein_44 sulfite exporter TauE/SafE family protein -
  E0E09_RS00265 - 54884..55501 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  E0E09_RS00270 - 55582..57996 (-) 2415 WP_000378487.1 cadmium-translocating P-type ATPase CadA -
  E0E09_RS00275 - 57989..58354 (-) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  E0E09_RS00280 - 58592..58969 (-) 378 WP_001041908.1 DUF6262 family protein -
  E0E09_RS00285 - 58976..60868 (-) 1893 WP_002485298.1 site-specific integrase -
  E0E09_RS00290 - 61063..61386 (-) 324 WP_000088091.1 JAB domain-containing protein -
  E0E09_RS00295 - 61379..61585 (-) 207 WP_001077283.1 hypothetical protein -
  E0E09_RS00300 - 61587..62108 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  E0E09_RS00305 - 62127..62438 (-) 312 WP_000833212.1 DUF960 family protein -
  E0E09_RS00315 - 62523..62873 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  E0E09_RS00320 ccrB 63344..64972 (-) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  E0E09_RS00325 ccrA 64993..66339 (-) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 52138.19 Da        Isoelectric Point: 10.1760

>NTDB_id=1115769 E0E09_RS00325 WP_000816499.1 64993..66339(-) (ccrA) [Staphylococcus aureus isolate BPH2869]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1115769 E0E09_RS00325 WP_000816499.1 64993..66339(-) (ccrA) [Staphylococcus aureus isolate BPH2869]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(168-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9R3W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

78.174

100

0.783
  ccrA Staphylococcus aureus N315

72.383

100

0.725

Multiple sequence alignment