Detailed information NTG1111482

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACN076_RS10050
• Genome accession: NZ_CP184836
• Coordinates: 2018701..2019738 (-)
• Length: 345 a.a.
• NCBI ID: WP_033683058.1
• Uniprot ID: A0A081QHR4
• Organism: Streptococcus sp. K0074
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2013701..2024738

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACN076_RS10025 (ACN076_10025)	-	2014576..2015907 (-)	1332	WP_101786092.1	hemolysin family protein	-
ACN076_RS10030 (ACN076_10030)	endA	2016062..2016886 (-)	825	WP_101786094.1	DNA-entry nuclease EndA	Machinery gene
ACN076_RS10035 (ACN076_10035)	-	2016925..2017113 (-)	189	WP_025169706.1	DNA-directed RNA polymerase subunit beta	-
ACN076_RS10040 (ACN076_10040)	murA	2017106..2018389 (-)	1284	WP_420789925.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
ACN076_RS10045 (ACN076_10045)	-	2018413..2018643 (-)	231	WP_000250399.1	DUF1146 family protein	-
ACN076_RS10050 (ACN076_10050)	sepM	2018701..2019738 (-)	1038	WP_033683058.1	SepM family pheromone-processing serine protease	Regulator
ACN076_RS10055 (ACN076_10055)	coaD	2019722..2020210 (-)	489	WP_420789926.1	pantetheine-phosphate adenylyltransferase	-
ACN076_RS10060 (ACN076_10060)	rsmD	2020200..2020739 (-)	540	WP_261072589.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACN076_RS10065 (ACN076_10065)	asnA	2020804..2021796 (-)	993	WP_000748005.1	aspartate--ammonia ligase	-
ACN076_RS10070 (ACN076_10070)	-	2021908..2022591 (-)	684	WP_101786098.1	Bax inhibitor-1 family protein	-
ACN076_RS10075 (ACN076_10075)	-	2022646..2023386 (-)	741	WP_101786100.1	TrmH family RNA methyltransferase	-
ACN076_RS10080 (ACN076_10080)	-	2023420..2023698 (+)	279	WP_420789927.1	acylphosphatase	-
ACN076_RS10085 (ACN076_10085)	yidC	2023776..2024702 (+)	927	WP_285300843.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37580.64 Da
• Isoelectric Point: 4.9714

>NTDB_id=1111482 ACN076_RS10050 WP_033683058.1 2018701..2019738(-) (sepM) [Streptococcus sp. K0074]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDKEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYLGVYVLTVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVNSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVTSDVPIRFSTAGIGGPSAGLMFSL
AIYTQIADPGLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASAREGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1111482 ACN076_RS10050 WP_033683058.1 2018701..2019738(-) (sepM) [Streptococcus sp. K0074]
ATGAAAAAAAAGATTAGATGGCCCTTATATGTCATTGCGGCCTTAATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
CTACTATATAGAAGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTCAATGACAAAGAAGATAAGGAAGCTG
GGGCCTATCAATTCGTTACAGTTGGTGTCCAACATGCTACTTTAGCTCATATGATTTATGCGTGGTTGACGCCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTAGAATTTATGCGGATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATTGAACTAAAATACCTTGGGGTTTATGTTT
TGACTGTGACAGATAATTCAACCTTTAAAGGGATTCTCAACATCTCTGATACCGTCACAGCAGTCAATGATCAGACCTTT
GACAGTTCCAAAGATTTGATTGATTATGTCAATTCTCAAAAATTAGGGGACTCTGTCAAAGTAACCTATGAAGAGGATGG
GCAAACCAAATCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAAGTAACCAGTGATGTCCCAATTCGCTTTTCAACAGCTGGTATCGGTGGTCCAAGTGCAGGTCTCATGTTTAGTCTA
GCCATCTATACCCAAATAGCAGACCCAGGCCTTCGTAATGGCCGCATTGTTGCCGGTACAGGAACCATTGACCGTGATGG
TAATGTGGGGGACATTGGAGGTATTGATAAGAAAGTTGTAGCTTCGGCTAGAGAAGGTGCTGCTATTTTCTTTGCCCCAG
ATAATCCTGTTAGCGAAGAAGAACAAAAAGCACATCCTGATGCGAAAAACAACTACCAAACAGCCCTAGAAGCAGCTAAA
ACAATCAAGACAGATATGAAAATCGTGCCAGTTAAAACCCTACAAGATGCAATTGATTACTTGAAAAACAATCCCTAG

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (129-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A081QHR4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.942	99.13	0.594