Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ACAM23_RS02205 Genome accession   NZ_AP031394
Coordinates   409359..410048 (+) Length   229 a.a.
NCBI ID   WP_000518008.1    Uniprot ID   A0A0B7KUQ5
Organism   Streptococcus pneumoniae strain 16P28     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 404359..415048
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM23_RS02180 (SPNE16P28_04270) gpsB 404492..404821 (+) 330 WP_000146522.1 cell division regulator GpsB -
  ACAM23_RS02190 (SPNE16P28_04280) - 405307..406464 (+) 1158 WP_000711385.1 class I SAM-dependent RNA methyltransferase -
  ACAM23_RS02195 (SPNE16P28_04290) mapZ 406477..407847 (+) 1371 WP_000039285.1 mid-cell-anchored protein MapZ -
  ACAM23_RS02200 (SPNE16P28_04300) gndA 407923..409347 (+) 1425 WP_000158781.1 NADP-dependent phosphogluconate dehydrogenase -
  ACAM23_RS02205 (SPNE16P28_04310) covR 409359..410048 (+) 690 WP_000518008.1 response regulator transcription factor Regulator
  ACAM23_RS02210 (SPNE16P28_04320) - 410146..411042 (+) 897 WP_050218315.1 choline-binding protein CbpC -
  ACAM23_RS02215 (SPNE16P28_04330) mvk 411164..412042 (+) 879 WP_050218314.1 mevalonate kinase -
  ACAM23_RS02220 (SPNE16P28_04340) mvaD 412024..412977 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  ACAM23_RS02225 (SPNE16P28_04350) - 412964..413971 (+) 1008 WP_369608081.1 phosphomevalonate kinase -
  ACAM23_RS02230 (SPNE16P28_04360) fni 413955..414965 (+) 1011 WP_000210619.1 type 2 isopentenyl-diphosphate Delta-isomerase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26914.21 Da        Isoelectric Point: 6.9836

>NTDB_id=108946 ACAM23_RS02205 WP_000518008.1 409359..410048(+) (covR) [Streptococcus pneumoniae strain 16P28]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVFIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=108946 ACAM23_RS02205 WP_000518008.1 409359..410048(+) (covR) [Streptococcus pneumoniae strain 16P28]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTTTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGTCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCTTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAACTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGTCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7KUQ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.261

100

0.485
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.522

100

0.467

Multiple sequence alignment