Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | ACHZEV_RS07330 | Genome accession | NZ_CP172401 |
| Coordinates | 1535370..1536719 (+) | Length | 449 a.a. |
| NCBI ID | WP_316050811.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain M22.2 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1491389..1540334 | 1535370..1536719 | within | 0 |
| SCCmec | 1491447..1537892 | 1535370..1536719 | within | 0 |
Gene organization within MGE regions
Location: 1491389..1540334
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACHZEV_RS07090 (ACHZEV_07090) | ccrC | 1491389..1493065 (-) | 1677 | WP_316133339.1 | cassette chromosome recombinase CcrC | - |
| ACHZEV_RS07095 (ACHZEV_07095) | - | 1493290..1494906 (-) | 1617 | WP_316133340.1 | DUF5906 domain-containing protein | - |
| ACHZEV_RS07100 (ACHZEV_07100) | - | 1494906..1495274 (-) | 369 | WP_031886427.1 | hypothetical protein | - |
| ACHZEV_RS07105 (ACHZEV_07105) | - | 1495267..1496367 (-) | 1101 | WP_031886426.1 | DNA polymerase | - |
| ACHZEV_RS07110 (ACHZEV_07110) | - | 1496578..1497903 (-) | 1326 | WP_031886425.1 | DUF6038 family protein | - |
| ACHZEV_RS07115 (ACHZEV_07115) | - | 1498089..1498826 (-) | 738 | WP_031886424.1 | Cthe_2314 family HEPN domain-containing protein | - |
| ACHZEV_RS07120 (ACHZEV_07120) | - | 1498856..1499290 (-) | 435 | WP_031886423.1 | hypothetical protein | - |
| ACHZEV_RS07125 (ACHZEV_07125) | - | 1499587..1500132 (-) | 546 | WP_037537668.1 | YdhK family protein | - |
| ACHZEV_RS07130 (ACHZEV_07130) | - | 1500150..1502210 (-) | 2061 | WP_025905371.1 | heavy metal translocating P-type ATPase | - |
| ACHZEV_RS07135 (ACHZEV_07135) | - | 1502479..1502796 (+) | 318 | WP_011274435.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| ACHZEV_RS07140 (ACHZEV_07140) | arsB | 1502793..1504085 (+) | 1293 | WP_316133344.1 | arsenite efflux transporter membrane subunit ArsB | - |
| ACHZEV_RS07145 (ACHZEV_07145) | arsC | 1504103..1504504 (+) | 402 | WP_151362629.1 | arsenate reductase (thioredoxin) | - |
| ACHZEV_RS07150 (ACHZEV_07150) | - | 1504524..1504865 (-) | 342 | WP_151362628.1 | helix-turn-helix transcriptional regulator | - |
| ACHZEV_RS07155 (ACHZEV_07155) | - | 1504884..1505501 (-) | 618 | WP_069826417.1 | CadD family cadmium resistance transporter | - |
| ACHZEV_RS07160 (ACHZEV_07160) | - | 1505772..1506344 (-) | 573 | WP_316133345.1 | ADP-ribosyltransferase | - |
| ACHZEV_RS07165 (ACHZEV_07165) | - | 1506675..1506989 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| ACHZEV_RS07170 (ACHZEV_07170) | - | 1507005..1507391 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| ACHZEV_RS07175 (ACHZEV_07175) | - | 1507420..1508805 (+) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| ACHZEV_RS07180 (ACHZEV_07180) | - | 1508808..1508960 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| ACHZEV_RS07185 (ACHZEV_07185) | mobT | 1508983..1510188 (+) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| ACHZEV_RS07190 (ACHZEV_07190) | - | 1510231..1510452 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| ACHZEV_RS07195 (ACHZEV_07195) | - | 1510569..1511066 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| ACHZEV_RS07200 (ACHZEV_07200) | - | 1511155..1511547 (+) | 393 | WP_316133341.1 | conjugal transfer protein | - |
| ACHZEV_RS07205 (ACHZEV_07205) | - | 1511531..1513978 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| ACHZEV_RS07210 (ACHZEV_07210) | - | 1513981..1516158 (+) | 2178 | WP_000804748.1 | CD3337/EF1877 family mobilome membrane protein | - |
| ACHZEV_RS07215 (ACHZEV_07215) | - | 1516155..1517156 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| ACHZEV_RS07220 (ACHZEV_07220) | - | 1517153..1518088 (+) | 936 | WP_001224320.1 | conjugal transfer protein | - |
| ACHZEV_RS07225 (ACHZEV_07225) | - | 1518402..1518449 (+) | 48 | Protein_1421 | hypothetical protein | - |
| ACHZEV_RS07230 (ACHZEV_07230) | tet(M) | 1518465..1520384 (+) | 1920 | WP_000691736.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| ACHZEV_RS07235 (ACHZEV_07235) | - | 1520503..1520670 (+) | 168 | WP_000336323.1 | cysteine-rich KTR domain-containing protein | - |
| ACHZEV_RS07240 (ACHZEV_07240) | - | 1520730..1521083 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| ACHZEV_RS07245 (ACHZEV_07245) | - | 1521588..1522010 (+) | 423 | WP_316133342.1 | sigma-70 family RNA polymerase sigma factor | - |
| ACHZEV_RS07250 (ACHZEV_07250) | - | 1522007..1522237 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| ACHZEV_RS07255 (ACHZEV_07255) | - | 1522463..1522714 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| ACHZEV_RS07260 (ACHZEV_07260) | - | 1522698..1522901 (+) | 204 | WP_000814511.1 | excisionase | - |
| ACHZEV_RS07265 (ACHZEV_07265) | - | 1522983..1523459 (+) | 477 | Protein_1429 | integrase DNA-binding domain-containing protein | - |
| ACHZEV_RS07270 (ACHZEV_07270) | - | 1523519..1524193 (-) | 675 | WP_001105994.1 | IS6-like element IS257 family transposase | - |
| ACHZEV_RS07275 (ACHZEV_07275) | - | 1524234..1524341 (-) | 108 | Protein_1431 | beta-lactam sensor/signal transducer MecR1 | - |
| ACHZEV_RS07280 (ACHZEV_07280) | mecA | 1524438..1526447 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ACHZEV_RS07285 (ACHZEV_07285) | - | 1526493..1526921 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| ACHZEV_RS07290 (ACHZEV_07290) | - | 1527018..1527761 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| ACHZEV_RS07295 (ACHZEV_07295) | - | 1528638..1529027 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| ACHZEV_RS07300 (ACHZEV_07300) | - | 1529063..1529737 (+) | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| ACHZEV_RS07305 (ACHZEV_07305) | - | 1530162..1531307 (+) | 1146 | WP_316133343.1 | DUF6038 family protein | - |
| ACHZEV_RS07310 (ACHZEV_07310) | - | 1531385..1532557 (+) | 1173 | WP_032495458.1 | IS256-like element ISEnfa4 family transposase | - |
| ACHZEV_RS07315 (ACHZEV_07315) | - | 1532661..1532921 (+) | 261 | WP_316133377.1 | DUF6038 family protein | - |
| ACHZEV_RS07320 (ACHZEV_07320) | cch1 | 1533047..1534834 (+) | 1788 | WP_044466492.1 | cassette chromosome replicative helicase | - |
| ACHZEV_RS07325 (ACHZEV_07325) | - | 1534903..1535178 (+) | 276 | WP_044466491.1 | hypothetical protein | - |
| ACHZEV_RS07330 (ACHZEV_07330) | ccrA | 1535370..1536719 (+) | 1350 | WP_316050811.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ACHZEV_RS07335 (ACHZEV_07335) | ccrB | 1536741..1538366 (+) | 1626 | WP_316133364.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ACHZEV_RS07340 (ACHZEV_07340) | - | 1538832..1539182 (+) | 351 | WP_053027485.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ACHZEV_RS07345 (ACHZEV_07345) | - | 1539269..1539580 (+) | 312 | WP_204170654.1 | DUF960 family protein | - |
| ACHZEV_RS07350 (ACHZEV_07350) | - | 1539595..1540098 (+) | 504 | WP_216347507.1 | DUF1643 domain-containing protein | - |
| ACHZEV_RS07355 (ACHZEV_07355) | - | 1540113..1540334 (+) | 222 | WP_135789028.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52347.88 Da Isoelectric Point: 9.9233
>NTDB_id=1067348 ACHZEV_RS07330 WP_316050811.1 1535370..1536719(+) (ccrA) [Staphylococcus aureus strain M22.2]
MKQAIGYLRQSTTKQQSLAAQKQTIKTLAEKHNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTIDTVKSPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPDHSLRYYVCPQNMNSARFVCEFKGINAQELETSVLAT
CQNFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPLSSISAYQIRKAFQ
NIIQERFTLNMLYPYIDEINISKNKTLAGIYFKNEPLNIVNQTTQSSIA
MKQAIGYLRQSTTKQQSLAAQKQTIKTLAEKHNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTIDTVKSPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPDHSLRYYVCPQNMNSARFVCEFKGINAQELETSVLAT
CQNFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPLSSISAYQIRKAFQ
NIIQERFTLNMLYPYIDEINISKNKTLAGIYFKNEPLNIVNQTTQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=1067348 ACHZEV_RS07330 WP_316050811.1 1535370..1536719(+) (ccrA) [Staphylococcus aureus strain M22.2]
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCAAGAC
ATTAGCCGAAAAACATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAAGGACAATGTGACGTACTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
TTGAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAACTGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAATCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCTCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTACGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAACCAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAGCGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGAACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTCTATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAAGAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAACAAAACCCT
TGCGGGGATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACTACGCAATCATCGATTGCTTAA
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCAAGAC
ATTAGCCGAAAAACATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAAGGACAATGTGACGTACTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
TTGAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAACTGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAATCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCTCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTACGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAACCAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAGCGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGAACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTCTATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAAGAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAACAAAACCCT
TGCGGGGATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACTACGCAATCATCGATTGCTTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
93.987 |
100 |
0.94 |
| ccrA | Staphylococcus aureus N315 |
75.056 |
100 |
0.751 |