Detailed information NTG1060341

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: ACF8MK_RS12265
• Genome accession: NZ_CP171154
• Coordinates: 2823747..2826479 (-)
• Length: 910 a.a.
• NCBI ID: WP_392536900.1
• Uniprot ID: -
• Organism: Legionella sp. 227
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2818747..2831479

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACF8MK_RS12240 (ACF8MK_12240)	-	2819095..2820501 (-)	1407	WP_392536897.1	APC family permease	-
ACF8MK_RS12245 (ACF8MK_12245)	-	2820745..2821089 (-)	345	WP_392536898.1	hypothetical protein	-
ACF8MK_RS12250 (ACF8MK_12250)	-	2821296..2821625 (-)	330	WP_392536899.1	BolA family protein	-
ACF8MK_RS12255 (ACF8MK_12255)	pilA2	2821692..2822123 (-)	432	WP_392538959.1	pilin	Machinery gene
ACF8MK_RS12260 (ACF8MK_12260)	-	2822432..2823670 (-)	1239	WP_265704355.1	6-phosphofructokinase	-
ACF8MK_RS12265 (ACF8MK_12265)	letS	2823747..2826479 (-)	2733	WP_392536900.1	two-component system sensor histidine kinase LetS	Regulator
ACF8MK_RS12270 (ACF8MK_12270)	gltX	2826656..2828071 (+)	1416	WP_392536901.1	glutamate--tRNA ligase	-
ACF8MK_RS12275 (ACF8MK_12275)	-	2828208..2829473 (+)	1266	WP_392536902.1	serine hydrolase domain-containing protein	-
ACF8MK_RS12280 (ACF8MK_12280)	-	2829744..2830727 (+)	984	WP_392536903.1	hypothetical protein	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 102845.16 Da
• Isoelectric Point: 7.2429

>NTDB_id=1060341 ACF8MK_RS12265 WP_392536900.1 2823747..2826479(-) (letS) [Legionella sp. 227]
MKSIGIKYQLRITTLIPAFLVALLLAIFYNGLFGNDLKQHMSRLGEAYIRQLLPAAQYAMLRRDDRTLQGLINASTINPE
VKALAFYSSDGQLLAYRGGKHSLNKPFNPPKFTGDYIESKQINPFTINFIAPVTIPKFNLYSNSSFKNILSPMTTRADDI
LGWLSIDIDTRSMIIKRYQMLIVTIFITLFGLLMGLTIHYFLSKRIYLPISRLRRSMKQILRNEFETEIKTSSPGELGII
EQGCSHLQKKYLETIRDLNQHIEIATEDLQQSLELLEEKNIELSLEKKKIEEKSRQKSEFIANMSHEIRTPMNGVIGFTN
VLLESKLDPLQLDYVKTIKASAQDLLGIINDILDFSKIDAGKLHLDCIPLNIRHCIDEVLTLAAPNAHKKGIDLIPITDV
SVPKIVLGDPFRIKQFITNLVTNAVKFTDHGYVLVRTKVEQETDKDYTLCITITDTGLGISPEDQSKLFTAFNQADTSIT
RRYGGSGLGLVICKKLCEEMHGRISFTSELNKGSSFTAHVKVEKLVAYEIEKNQIHPFAHFKMLCFDDNSLHLEALCNGL
GYWGIQCIPVNSFNQLASALENNKDCNIAFLNINRGYEQKIAKIIAEHNYFPYVLISKWLINDYTALGAQGFLYKPISIQ
KLQDVIESLTSQENIEKPVNHELDGLREQLRFMHPDLLIAEDNPVNKMLLDSLLGTHANMTSVDDGEMAVAACNDKKYDL
ILLDLQMPKVNGLEAARLIRQKSQLNRHTPIVLISANGSDVNSIDLKKSGVDFCLQKPIDEKQLLTQILRIADKAKHAAI
DWQLCVQKVSGNQALAEEFLSRFVEELHKNREEFIQLMHDKNIKKIGEAAHKLHGACCFSGVPTLQKKVVQVEKLAAHTV
SIEELATPFAELIQSIDAVINEYEHQKIRI

Nucleotide

• Length: 2733 bp

>NTDB_id=1060341 ACF8MK_RS12265 WP_392536900.1 2823747..2826479(-) (letS) [Legionella sp. 227]
TTGAAAAGCATAGGTATCAAGTATCAACTGAGAATTACCACCCTAATTCCAGCCTTTTTAGTCGCCCTGCTTCTCGCTAT
TTTTTATAATGGACTGTTTGGTAATGACTTAAAACAGCACATGTCTCGTCTGGGCGAAGCATACATCCGTCAACTACTTC
CTGCAGCACAATACGCCATGCTTCGACGTGACGATCGCACGTTGCAAGGGTTAATTAATGCATCCACAATCAATCCAGAA
GTAAAAGCTCTCGCTTTTTACAGTAGTGATGGACAACTGCTGGCTTACCGCGGTGGCAAACATTCCCTGAATAAACCCTT
CAATCCTCCTAAATTTACGGGGGATTATATTGAAAGTAAGCAAATTAATCCTTTTACCATTAACTTCATCGCACCTGTTA
CTATTCCTAAATTCAATCTTTATTCTAATTCGTCTTTTAAGAACATCCTCAGCCCAATGACCACTCGCGCAGATGATATT
TTAGGTTGGTTATCCATTGATATTGATACTCGCTCGATGATTATCAAACGTTATCAAATGCTCATTGTAACCATCTTTAT
TACTCTTTTTGGTTTGCTCATGGGATTGACCATACACTACTTTCTCTCTAAGCGTATTTATTTGCCTATTTCCCGTTTAC
GTCGGAGCATGAAACAAATTTTACGCAATGAATTCGAAACAGAAATCAAAACATCGAGTCCAGGCGAACTAGGCATCATT
GAGCAAGGATGCTCCCATTTGCAAAAAAAATACCTCGAAACAATACGTGACTTAAATCAACACATCGAAATAGCCACTGA
AGATTTACAACAAAGTCTTGAATTGTTAGAAGAAAAAAATATCGAGCTCTCACTTGAGAAGAAGAAAATAGAAGAAAAAA
GTCGGCAAAAATCAGAATTTATTGCCAATATGAGTCATGAAATCCGTACACCAATGAATGGAGTTATTGGCTTTACTAAT
GTTTTATTGGAAAGCAAGCTTGATCCCTTGCAATTAGATTATGTAAAAACAATCAAAGCTTCTGCACAAGATTTGTTAGG
AATTATTAATGATATCCTCGATTTTTCTAAAATTGATGCGGGAAAACTTCACCTGGATTGCATCCCCTTAAATATCCGTC
ATTGTATCGATGAAGTGCTTACCCTTGCAGCACCAAATGCTCATAAAAAAGGTATTGATTTAATCCCCATAACCGATGTC
AGTGTACCTAAAATTGTTTTAGGTGATCCCTTTAGAATCAAACAATTTATCACCAATCTAGTGACTAATGCGGTTAAATT
TACCGATCATGGTTATGTATTGGTCCGCACTAAAGTAGAACAAGAAACAGATAAAGATTACACTTTATGCATCACAATAA
CTGATACTGGTTTAGGTATTTCTCCAGAGGATCAAAGTAAATTATTTACTGCATTTAATCAGGCCGATACAAGCATTACT
CGGCGTTATGGCGGTTCAGGTCTAGGATTAGTCATTTGTAAAAAGCTCTGTGAAGAAATGCATGGGCGTATCAGCTTTAC
CAGCGAGCTCAATAAAGGTTCTAGCTTCACTGCTCACGTGAAGGTTGAAAAGTTAGTTGCCTATGAAATAGAAAAAAATC
AAATACACCCCTTCGCGCATTTTAAAATGTTATGCTTTGATGATAATTCGCTCCATTTGGAAGCACTATGCAATGGCTTA
GGTTATTGGGGAATTCAATGTATTCCCGTAAATTCGTTTAACCAACTTGCGAGTGCTCTTGAGAATAACAAAGACTGTAA
TATTGCTTTTCTCAATATCAATAGAGGTTATGAACAAAAGATAGCCAAAATCATTGCCGAACATAATTATTTTCCATACG
TGCTCATTTCCAAATGGCTTATTAATGATTACACAGCTCTTGGAGCTCAGGGCTTTTTATATAAACCCATCAGCATTCAA
AAACTTCAAGATGTTATTGAATCCCTCACCAGCCAAGAGAACATTGAAAAACCGGTCAATCATGAATTGGATGGTTTAAG
AGAACAACTACGCTTTATGCACCCTGATTTACTCATTGCCGAAGACAACCCAGTTAACAAAATGCTCCTGGACTCTTTAT
TGGGCACTCATGCAAATATGACTTCAGTTGATGACGGTGAAATGGCCGTAGCGGCGTGTAATGACAAAAAATACGACCTC
ATTTTGCTCGATTTGCAGATGCCTAAAGTCAATGGATTAGAAGCAGCCCGACTCATTCGACAAAAATCACAACTTAACCG
CCATACCCCTATTGTTTTAATTAGCGCGAATGGCAGCGATGTGAATAGCATTGATTTAAAAAAATCAGGTGTGGATTTTT
GCTTGCAAAAACCTATAGATGAAAAACAATTACTAACCCAAATCCTGCGGATTGCCGATAAAGCAAAACATGCAGCAATT
GATTGGCAGTTATGTGTGCAAAAAGTGTCTGGAAATCAAGCACTTGCGGAAGAGTTTCTTAGCCGATTCGTGGAGGAATT
ACATAAAAATCGTGAAGAATTTATCCAATTAATGCATGATAAAAATATTAAAAAAATTGGCGAAGCCGCACATAAACTGC
ATGGAGCATGTTGTTTTTCTGGAGTGCCAACGCTGCAAAAAAAAGTAGTACAGGTAGAAAAACTGGCAGCACACACTGTT
TCAATTGAAGAGCTCGCCACTCCTTTTGCCGAATTAATTCAAAGCATTGATGCAGTAATTAATGAATATGAACATCAAAA
AATAAGAATTTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (297-361)

• Hpt domain (Hpt) (818-899)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (408-523)

• Single cache domain 4 (sCache_4) (35-179)

• Response regulator receiver domain (Response_reg) (678-788)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	79.912	99.56	0.796