Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACFIOU_RS10345 Genome accession   NZ_CP170426
Coordinates   2040043..2040672 (-) Length   209 a.a.
NCBI ID   WP_000153536.1    Uniprot ID   A0A481NSD5
Organism   Staphylococcus aureus strain t1492     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2035043..2045672
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACFIOU_RS10315 - 2035464..2035994 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  ACFIOU_RS10320 - 2036084..2037340 (-) 1257 WP_072419726.1 aminopeptidase -
  ACFIOU_RS10325 - 2037343..2037543 (-) 201 WP_000180460.1 DUF1128 family protein -
  ACFIOU_RS10330 - 2037690..2038154 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  ACFIOU_RS10335 - 2038161..2038436 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  ACFIOU_RS10340 - 2038714..2039931 (+) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  ACFIOU_RS10345 vraR 2040043..2040672 (-) 630 WP_000153536.1 two-component system response regulator VraR Regulator
  ACFIOU_RS10350 vraS 2040662..2041705 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  ACFIOU_RS10355 liaF 2041702..2042403 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  ACFIOU_RS10360 - 2042418..2042804 (-) 387 WP_001110179.1 hypothetical protein -
  ACFIOU_RS10365 map 2043021..2043779 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  ACFIOU_RS10370 - 2044195..2045181 (+) 987 WP_000999713.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23490.21 Da        Isoelectric Point: 5.1703

>NTDB_id=1057205 ACFIOU_RS10345 WP_000153536.1 2040043..2040672(-) (vraR) [Staphylococcus aureus strain t1492]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSSGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=1057205 ACFIOU_RS10345 WP_000153536.1 2040043..2040672(-) (vraR) [Staphylococcus aureus strain t1492]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGCGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSD5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment