Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   DK93_RS02485 Genome accession   NZ_CP007562
Coordinates   493096..493737 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain NGAS327     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 488096..498737
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK93_RS02465 (DK93_02555) - 488652..489392 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DK93_RS02470 (DK93_02560) pknB 489389..491287 (+) 1899 WP_038431490.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DK93_RS02475 (DK93_02565) liaF 491410..492102 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  DK93_RS02480 (DK93_02570) - 492099..493103 (+) 1005 WP_038431487.1 sensor histidine kinase -
  DK93_RS02485 (DK93_02575) vraR 493096..493737 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  DK93_RS02490 (DK93_02580) - 493774..495174 (+) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DK93_RS02495 (DK93_02585) - 495174..495551 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  DK93_RS02500 (DK93_02590) cysK 495569..496510 (-) 942 WP_038431485.1 cysteine synthase A -
  DK93_RS02505 (DK93_02595) - 496638..497270 (-) 633 WP_002988970.1 YigZ family protein -
  DK93_RS02510 (DK93_02600) comFA/cflA 497325..498650 (+) 1326 WP_002988971.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=105709 DK93_RS02485 WP_002983671.1 493096..493737(+) (vraR) [Streptococcus pyogenes strain NGAS327]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=105709 DK93_RS02485 WP_002983671.1 493096..493737(+) (vraR) [Streptococcus pyogenes strain NGAS327]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment