Detailed information NTG1056880

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOR_RS04370
• Genome accession: NZ_CP170409
• Coordinates: 845880..846923 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t359
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 840880..851923

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOR_RS04340	-	841310..841420 (+)	111	WP_112386585.1	hypothetical protein	-
ACFIOR_RS04345	-	841449..841862 (+)	414	WP_001549145.1	hypothetical protein	-
ACFIOR_RS04350	-	842293..843279 (-)	987	WP_000999713.1	FUSC family protein	-
ACFIOR_RS04355	map	843810..844592 (+)	783	WP_168768559.1	type I methionyl aminopeptidase	-
ACFIOR_RS04360	-	844781..845167 (+)	387	WP_001110179.1	hypothetical protein	-
ACFIOR_RS04365	liaF	845182..845883 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOR_RS04370	vraS	845880..846923 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOR_RS04375	vraR	846913..847542 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOR_RS04380	-	847654..848871 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
ACFIOR_RS04385	-	849149..849424 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOR_RS04390	-	849431..849895 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOR_RS04395	-	850042..850242 (+)	201	WP_000180463.1	DUF1128 family protein	-
ACFIOR_RS04400	-	850245..851501 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1056880 ACFIOR_RS04370 WP_001017131.1 845880..846923(+) (vraS) [Staphylococcus aureus strain t359]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1056880 ACFIOR_RS04370 WP_001017131.1 845880..846923(+) (vraS) [Staphylococcus aureus strain t359]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1