Detailed information
Bioinformatically predicted
Overview
| Name | vraR | Type | Regulator |
| Locus tag | ACFDHS_RS05355 | Genome accession | NZ_CP170235 |
| Coordinates | 1103374..1104003 (+) | Length | 209 a.a. |
| NCBI ID | WP_039644795.1 | Uniprot ID | A0A0A8HRY9 |
| Organism | Staphylococcus hyicus strain SC362 | ||
| Function | repress expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1084029..1136230 | 1103374..1104003 | within | 0 |
Gene organization within MGE regions
Location: 1084029..1136230
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACFDHS_RS05265 (ACFDHS_05265) | putP | 1084583..1086127 (-) | 1545 | WP_039644773.1 | sodium/proline symporter PutP | - |
| ACFDHS_RS05270 (ACFDHS_05270) | gatC | 1086539..1086841 (+) | 303 | WP_037566951.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| ACFDHS_RS05275 (ACFDHS_05275) | gatA | 1086844..1088304 (+) | 1461 | WP_107633467.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| ACFDHS_RS05280 (ACFDHS_05280) | gatB | 1088318..1089745 (+) | 1428 | WP_039644777.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| ACFDHS_RS05285 (ACFDHS_05285) | - | 1089986..1090918 (+) | 933 | WP_107633465.1 | diacylglycerol kinase | - |
| ACFDHS_RS05290 (ACFDHS_05290) | rlmD | 1091019..1092389 (+) | 1371 | WP_039644779.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| ACFDHS_RS05295 (ACFDHS_05295) | - | 1092401..1093714 (+) | 1314 | WP_305850350.1 | carboxylesterase family protein | - |
| ACFDHS_RS05300 (ACFDHS_05300) | - | 1093812..1094351 (+) | 540 | WP_039644780.1 | metalloprotease family protein | - |
| ACFDHS_RS05305 (ACFDHS_05305) | dinB | 1094540..1095610 (+) | 1071 | WP_039644781.1 | DNA polymerase IV | - |
| ACFDHS_RS05310 (ACFDHS_05310) | - | 1095605..1096165 (-) | 561 | WP_305850349.1 | 3'-5' exonuclease | - |
| ACFDHS_RS05315 (ACFDHS_05315) | - | 1096263..1096766 (-) | 504 | WP_039644783.1 | ferritin | - |
| ACFDHS_RS05320 (ACFDHS_05320) | - | 1096914..1098224 (+) | 1311 | WP_305850348.1 | Mur ligase family protein | - |
| ACFDHS_RS05325 (ACFDHS_05325) | - | 1098225..1098956 (+) | 732 | WP_305850347.1 | type 1 glutamine amidotransferase | - |
| ACFDHS_RS05330 (ACFDHS_05330) | - | 1099068..1100093 (-) | 1026 | WP_039644788.1 | aromatic acid exporter family protein | - |
| ACFDHS_RS05335 (ACFDHS_05335) | map | 1100387..1101145 (+) | 759 | WP_107633460.1 | type I methionyl aminopeptidase | - |
| ACFDHS_RS05340 (ACFDHS_05340) | - | 1101244..1101630 (+) | 387 | WP_052257806.1 | hypothetical protein | - |
| ACFDHS_RS05345 (ACFDHS_05345) | liaF | 1101643..1102344 (+) | 702 | WP_107633459.1 | cell wall-active antibiotics response protein LiaF | - |
| ACFDHS_RS05350 (ACFDHS_05350) | vraS | 1102341..1103384 (+) | 1044 | WP_380572727.1 | sensor histidine kinase | Regulator |
| ACFDHS_RS05355 (ACFDHS_05355) | vraR | 1103374..1104003 (+) | 630 | WP_039644795.1 | response regulator transcription factor | Regulator |
| ACFDHS_RS05360 (ACFDHS_05360) | - | 1104067..1104636 (-) | 570 | WP_039644796.1 | carbonic anhydrase | - |
| ACFDHS_RS05365 (ACFDHS_05365) | - | 1104671..1105942 (-) | 1272 | WP_107633458.1 | YihY/virulence factor BrkB family protein | - |
| ACFDHS_RS05370 (ACFDHS_05370) | - | 1106062..1106337 (-) | 276 | WP_039644801.1 | hypothetical protein | - |
| ACFDHS_RS05375 (ACFDHS_05375) | - | 1106344..1106802 (-) | 459 | WP_039644802.1 | low molecular weight protein-tyrosine-phosphatase | - |
| ACFDHS_RS05380 (ACFDHS_05380) | - | 1106935..1107144 (+) | 210 | WP_039644804.1 | DUF1128 family protein | - |
| ACFDHS_RS05385 (ACFDHS_05385) | - | 1107161..1108396 (+) | 1236 | WP_039644805.1 | aminopeptidase | - |
| ACFDHS_RS05390 (ACFDHS_05390) | - | 1108410..1108928 (+) | 519 | WP_039644807.1 | acyl-CoA thioesterase | - |
| ACFDHS_RS05395 (ACFDHS_05395) | yfkAB | 1109056..1110189 (-) | 1134 | WP_039644810.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| ACFDHS_RS05400 (ACFDHS_05400) | - | 1110301..1110462 (+) | 162 | WP_167694559.1 | SE1561 family protein | - |
| ACFDHS_RS05405 (ACFDHS_05405) | - | 1110530..1111048 (+) | 519 | WP_039644812.1 | type 1 glutamine amidotransferase domain-containing protein | - |
| ACFDHS_RS05410 (ACFDHS_05410) | - | 1111246..1111680 (-) | 435 | Protein_1027 | transposase | - |
| ACFDHS_RS05415 (ACFDHS_05415) | - | 1111804..1112088 (+) | 285 | WP_031867686.1 | hypothetical protein | - |
| ACFDHS_RS05420 (ACFDHS_05420) | - | 1112257..1112577 (+) | 321 | WP_031863810.1 | DUF961 family protein | - |
| ACFDHS_RS05425 (ACFDHS_05425) | - | 1112593..1112898 (+) | 306 | WP_031863809.1 | hypothetical protein | - |
| ACFDHS_RS05430 (ACFDHS_05430) | - | 1113063..1114145 (+) | 1083 | WP_031912235.1 | replication initiation factor domain-containing protein | - |
| ACFDHS_RS05435 (ACFDHS_05435) | - | 1114229..1115281 (+) | 1053 | WP_031867685.1 | conjugal transfer protein | - |
| ACFDHS_RS05440 (ACFDHS_05440) | - | 1115285..1115545 (+) | 261 | WP_031863806.1 | TcpD family membrane protein | - |
| ACFDHS_RS05445 (ACFDHS_05445) | - | 1115557..1115940 (+) | 384 | WP_031912234.1 | TcpE family conjugal transfer membrane protein | - |
| ACFDHS_RS05450 (ACFDHS_05450) | - | 1115975..1118470 (+) | 2496 | WP_031867684.1 | ATP-binding protein | - |
| ACFDHS_RS05455 (ACFDHS_05455) | - | 1118482..1119876 (+) | 1395 | WP_380572729.1 | FtsK/SpoIIIE domain-containing protein | - |
| ACFDHS_RS05460 (ACFDHS_05460) | - | 1119892..1121751 (+) | 1860 | WP_031912232.1 | CD3337/EF1877 family mobilome membrane protein | - |
| ACFDHS_RS05465 (ACFDHS_05465) | - | 1121741..1122778 (+) | 1038 | WP_031912231.1 | CHAP domain-containing protein | - |
| ACFDHS_RS05470 (ACFDHS_05470) | - | 1122783..1123370 (+) | 588 | WP_031912230.1 | hypothetical protein | - |
| ACFDHS_RS05475 (ACFDHS_05475) | - | 1123420..1123773 (+) | 354 | WP_031912229.1 | cystatin-like fold lipoprotein | - |
| ACFDHS_RS05480 (ACFDHS_05480) | - | 1123884..1124387 (+) | 504 | WP_031912228.1 | helix-turn-helix domain-containing protein | - |
| ACFDHS_RS05485 (ACFDHS_05485) | - | 1124425..1124904 (+) | 480 | WP_230373782.1 | IS30 family transposase | - |
| ACFDHS_RS05490 (ACFDHS_05490) | - | 1124984..1125820 (-) | 837 | WP_380572732.1 | transposase | - |
| ACFDHS_RS05495 (ACFDHS_05495) | - | 1126154..1127899 (-) | 1746 | WP_305850506.1 | pyruvate oxidase | - |
| ACFDHS_RS05500 (ACFDHS_05500) | sgtB | 1128067..1128873 (+) | 807 | WP_039644816.1 | monofunctional peptidoglycan glycosyltransferase SgtB | - |
| ACFDHS_RS05505 (ACFDHS_05505) | recX | 1128962..1129768 (+) | 807 | WP_305850507.1 | recombination regulator RecX | - |
| ACFDHS_RS05510 (ACFDHS_05510) | - | 1129758..1130069 (+) | 312 | WP_305850508.1 | YfhH family protein | - |
| ACFDHS_RS05515 (ACFDHS_05515) | - | 1130084..1131610 (+) | 1527 | WP_107633791.1 | ATP-binding cassette domain-containing protein | - |
| ACFDHS_RS05520 (ACFDHS_05520) | - | 1131619..1132389 (+) | 771 | WP_039644826.1 | teichoic acid translocation permease | - |
| ACFDHS_RS05525 (ACFDHS_05525) | - | 1132536..1133513 (-) | 978 | WP_107633792.1 | metal-dependent hydrolase | - |
| ACFDHS_RS05530 (ACFDHS_05530) | mutY | 1133602..1134651 (+) | 1050 | WP_305850509.1 | A/G-specific adenine glycosylase | - |
| ACFDHS_RS05535 (ACFDHS_05535) | - | 1134707..1135252 (+) | 546 | WP_107633794.1 | DUF402 domain-containing protein | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23540.17 Da Isoelectric Point: 5.1671
>NTDB_id=1055741 ACFDHS_RS05355 WP_039644795.1 1103374..1104003(+) (vraR) [Staphylococcus hyicus strain SC362]
MTIKVLFVDDHEMVRIGISSYLSTQPDIEVVGEGASGKEAITKAHELQPDLILMDLVMTDMDGVEATTQIKKDLPRIKVV
MLTSYIEDKEVYRALDAGVDSYILKTTSASDIAEAIRKTHKGESVFEAEVLVKMRNRMRQRAELYELLTEREMEILLLIS
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHGLIE
MTIKVLFVDDHEMVRIGISSYLSTQPDIEVVGEGASGKEAITKAHELQPDLILMDLVMTDMDGVEATTQIKKDLPRIKVV
MLTSYIEDKEVYRALDAGVDSYILKTTSASDIAEAIRKTHKGESVFEAEVLVKMRNRMRQRAELYELLTEREMEILLLIS
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHGLIE
Nucleotide
Download Length: 630 bp
>NTDB_id=1055741 ACFDHS_RS05355 WP_039644795.1 1103374..1104003(+) (vraR) [Staphylococcus hyicus strain SC362]
ATGACAATTAAAGTATTATTTGTGGATGATCATGAAATGGTAAGAATTGGAATATCAAGTTATCTTTCAACTCAACCAGA
TATTGAAGTAGTTGGTGAAGGAGCATCGGGTAAAGAAGCGATTACGAAGGCGCATGAACTTCAACCGGATTTGATTTTAA
TGGACTTAGTGATGACAGATATGGATGGTGTAGAAGCGACGACTCAAATTAAAAAAGATTTACCACGTATTAAAGTCGTG
ATGCTTACAAGCTATATTGAAGATAAAGAAGTTTACCGTGCGTTAGATGCAGGGGTGGACAGTTATATATTAAAAACAAC
AAGTGCAAGCGATATAGCCGAAGCAATTCGTAAAACACATAAAGGTGAATCTGTTTTTGAAGCTGAAGTACTAGTGAAAA
TGCGAAATCGTATGAGACAAAGAGCAGAACTTTATGAATTATTAACGGAACGTGAAATGGAAATATTGTTACTGATTTCC
AAAGGTTACTCAAATCAGGAAATTGCGAGTGCCTCTCATATTACGATAAAGACGGTAAAAACGCATGTCAGTAACATTTT
AAGTAAGCTTGAAGTACAAGACCGTACACAAGCAGTTATTTATGCCTTTCAACATGGCTTAATTGAATAA
ATGACAATTAAAGTATTATTTGTGGATGATCATGAAATGGTAAGAATTGGAATATCAAGTTATCTTTCAACTCAACCAGA
TATTGAAGTAGTTGGTGAAGGAGCATCGGGTAAAGAAGCGATTACGAAGGCGCATGAACTTCAACCGGATTTGATTTTAA
TGGACTTAGTGATGACAGATATGGATGGTGTAGAAGCGACGACTCAAATTAAAAAAGATTTACCACGTATTAAAGTCGTG
ATGCTTACAAGCTATATTGAAGATAAAGAAGTTTACCGTGCGTTAGATGCAGGGGTGGACAGTTATATATTAAAAACAAC
AAGTGCAAGCGATATAGCCGAAGCAATTCGTAAAACACATAAAGGTGAATCTGTTTTTGAAGCTGAAGTACTAGTGAAAA
TGCGAAATCGTATGAGACAAAGAGCAGAACTTTATGAATTATTAACGGAACGTGAAATGGAAATATTGTTACTGATTTCC
AAAGGTTACTCAAATCAGGAAATTGCGAGTGCCTCTCATATTACGATAAAGACGGTAAAAACGCATGTCAGTAACATTTT
AAGTAAGCTTGAAGTACAAGACCGTACACAAGCAGTTATTTATGCCTTTCAACATGGCTTAATTGAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| vraR | Staphylococcus aureus N315 |
90.431 |
100 |
0.904 |
| degU | Bacillus subtilis subsp. subtilis str. 168 |
35.714 |
100 |
0.383 |