Detailed information NTG1043730

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: ACD268_RS09065
• Genome accession: NZ_CP168299
• Coordinates: 1782657..1783346 (-)
• Length: 229 a.a.
• NCBI ID: WP_373381820.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain FC1
• Function: repress comR expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	1775154..1784782	1782657..1783346	within	0

Gene organization within MGE regions

Location: 1775154..1784782

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD268_RS09020 (ACD268_09020)	mvk	1775154..1776032 (-)	879	WP_000163315.1	mevalonate kinase	-
ACD268_RS09025 (ACD268_09025)	-	1776154..1776276 (-)	123	Protein_1788	hypothetical protein	-
ACD268_RS09030 (ACD268_09030)	-	1776316..1776483 (-)	168	Protein_1789	transposase	-
ACD268_RS09035 (ACD268_09035)	-	1777094..1777482 (+)	389	Protein_1790	lanthionine synthetase LanC family protein	-
ACD268_RS09040 (ACD268_09040)	-	1778011..1779003 (+)	993	Protein_1791	MFS transporter permease	-
ACD268_RS09045 (ACD268_09045)	-	1779022..1779975 (-)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
ACD268_RS09050 (ACD268_09050)	-	1780228..1780488 (+)	261	Protein_1793	MFS transporter permease	-
ACD268_RS09055 (ACD268_09055)	cbpJ	1780607..1781517 (-)	911	Protein_1794	choline-binding protein CbpJ	-
ACD268_RS09060 (ACD268_09060)	cbpC	1781536..1782558 (-)	1023	WP_330789298.1	choline-binding protein CbpC	-
ACD268_RS09065 (ACD268_09065)	covR	1782657..1783346 (-)	690	WP_373381820.1	response regulator transcription factor	Regulator
ACD268_RS09070 (ACD268_09070)	gndA	1783358..1784782 (-)	1425	WP_000158795.1	NADP-dependent phosphogluconate dehydrogenase	-

Sequence

Protein

• Length: 229 a.a.
• Molecular weight: 26852.13 Da
• Isoelectric Point: 6.9836

>NTDB_id=1043730 ACD268_RS09065 WP_373381820.1 1782657..1783346(-) (covR) [Streptococcus pneumoniae strain FC1]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDAEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide

• Length: 690 bp

>NTDB_id=1043730 ACD268_RS09065 WP_373381820.1 1782657..1783346(-) (covR) [Streptococcus pneumoniae strain FC1]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGCCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCCTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGCTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGCCAAA
AAAGCTACATTAAAACTGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-226)

• Response regulator receiver domain (Response_reg) (5-114)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Streptococcus salivarius strain HSISS4	47.826	100	0.48
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.522	100	0.467