Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACCK28_RS10145 Genome accession   NZ_CP168158
Coordinates   2046613..2047242 (-) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain CUBIST-49     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2041613..2052242
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACCK28_RS10115 (ACCK28_10115) - 2042030..2042560 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  ACCK28_RS10120 (ACCK28_10120) - 2042650..2043906 (-) 1257 WP_001795438.1 aminopeptidase -
  ACCK28_RS10125 (ACCK28_10125) - 2043909..2044109 (-) 201 WP_000180461.1 DUF1128 family protein -
  ACCK28_RS10130 (ACCK28_10130) - 2044256..2044720 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  ACCK28_RS10135 (ACCK28_10135) - 2044727..2045002 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  ACCK28_RS10140 (ACCK28_10140) - 2045280..2046497 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  ACCK28_RS10145 (ACCK28_10145) vraR 2046613..2047242 (-) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  ACCK28_RS10150 (ACCK28_10150) vraS 2047232..2048275 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  ACCK28_RS10155 (ACCK28_10155) liaF 2048272..2048973 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  ACCK28_RS10160 (ACCK28_10160) - 2048988..2049374 (-) 387 WP_001110179.1 hypothetical protein -
  ACCK28_RS10165 (ACCK28_10165) map 2049591..2050349 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  ACCK28_RS10170 (ACCK28_10170) - 2050877..2051863 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=1042801 ACCK28_RS10145 WP_000153530.1 2046613..2047242(-) (vraR) [Staphylococcus aureus strain CUBIST-49]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=1042801 ACCK28_RS10145 WP_000153530.1 2046613..2047242(-) (vraR) [Staphylococcus aureus strain CUBIST-49]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment