Detailed information NTG1037337

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACB352_RS09850
• Genome accession: NZ_CP167009
• Coordinates: 1927188..1928411 (+)
• Length: 407 a.a.
• NCBI ID: WP_011285340.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 22
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1922188..1933411

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB352_RS09835 (ACB352_09835)	-	1925327..1926101 (-)	775	Protein_1878	IS30 family transposase	-
ACB352_RS09845 (ACB352_09845)	rlmH	1926497..1926976 (-)	480	WP_002981964.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACB352_RS09850 (ACB352_09850)	htrA	1927188..1928411 (+)	1224	WP_011285340.1	S1C family serine protease	Regulator
ACB352_RS09855 (ACB352_09855)	spo0J	1928500..1929276 (+)	777	WP_021340715.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42786.41 Da
• Isoelectric Point: 7.3103

>NTDB_id=1037337 ACB352_RS09850 WP_011285340.1 1927188..1928411(+) (htrA) [Streptococcus pyogenes strain Isolate 22]
MPSMKYILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=1037337 ACB352_RS09850 WP_011285340.1 1927188..1928411(+) (htrA) [Streptococcus pyogenes strain Isolate 22]
ATGCCAAGTATGAAATATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGAATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGACGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.224	98.771	0.545
htrA	Streptococcus mitis NCTC 12261	53.071	100	0.531
htrA	Streptococcus pneumoniae Rx1	53.383	98.034	0.523
htrA	Streptococcus pneumoniae D39	53.383	98.034	0.523
htrA	Streptococcus pneumoniae R6	53.383	98.034	0.523
htrA	Streptococcus pneumoniae TIGR4	53.383	98.034	0.523