Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   ACB348_RS00805 Genome accession   NZ_CP167002
Coordinates   119733..120686 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain Isolate 30     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 114733..125686
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB348_RS00765 (ACB348_00765) - 115560..115925 (+) 366 WP_002986560.1 DUF1033 family protein -
  ACB348_RS00770 (ACB348_00770) comYA 116018..116956 (+) 939 WP_111704879.1 competence type IV pilus ATPase ComGA Machinery gene
  ACB348_RS00775 (ACB348_00775) comYB 116892..117926 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  ACB348_RS00780 (ACB348_00780) comYC 117928..118254 (+) 327 WP_032465607.1 competence type IV pilus major pilin ComGC Machinery gene
  ACB348_RS00785 (ACB348_00785) comGD 118229..118657 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  ACB348_RS00790 (ACB348_00790) comGE 118614..118898 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  ACB348_RS00795 (ACB348_00795) comYF 118891..119325 (+) 435 WP_023612536.1 competence type IV pilus minor pilin ComGF Machinery gene
  ACB348_RS00800 (ACB348_00800) comGG 119309..119635 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  ACB348_RS00805 (ACB348_00805) comYH 119733..120686 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  ACB348_RS00810 (ACB348_00810) - 120745..121941 (+) 1197 WP_023612537.1 acetate kinase -
  ACB348_RS00815 (ACB348_00815) - 122128..122436 (+) 309 WP_030126458.1 hypothetical protein -
  ACB348_RS00820 (ACB348_00820) proC 122519..123289 (-) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -
  ACB348_RS00825 (ACB348_00825) pepA 123337..124404 (-) 1068 WP_023613120.1 glutamyl aminopeptidase -
  ACB348_RS00830 (ACB348_00830) - 124869..125153 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  ACB348_RS00835 (ACB348_00835) - 125150..125467 (+) 318 WP_002986515.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=1036903 ACB348_RS00805 WP_002987790.1 119733..120686(+) (comYH) [Streptococcus pyogenes strain Isolate 30]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=1036903 ACB348_RS00805 WP_002987790.1 119733..120686(+) (comYH) [Streptococcus pyogenes strain Isolate 30]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAAATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACACTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment