Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   DQN36_RS02675 Genome accession   NZ_LS483425
Coordinates   510436..511077 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain NCTC13737     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 505436..516077
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN36_RS02655 (NCTC13737_00525) - 505992..506732 (+) 741 WP_032460192.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DQN36_RS02660 (NCTC13737_00526) pknB 506729..508627 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DQN36_RS02665 (NCTC13737_00527) liaF 508750..509442 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  DQN36_RS02670 (NCTC13737_00528) - 509439..510443 (+) 1005 WP_002991890.1 sensor histidine kinase -
  DQN36_RS02675 (NCTC13737_00529) vraR 510436..511077 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  DQN36_RS02680 (NCTC13737_00530) - 511114..512514 (+) 1401 WP_111704061.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQN36_RS02685 (NCTC13737_00531) - 512514..512891 (+) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  DQN36_RS02690 (NCTC13737_00532) cysK 512909..513850 (-) 942 WP_011888673.1 cysteine synthase A -
  DQN36_RS02695 (NCTC13737_00533) - 513978..514610 (-) 633 WP_009880468.1 YigZ family protein -
  DQN36_RS02700 (NCTC13737_00534) - 514666..515992 (+) 1327 Protein_465 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=1024298 DQN36_RS02675 WP_002983671.1 510436..511077(+) (vraR) [Streptococcus pyogenes strain NCTC13737]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=1024298 DQN36_RS02675 WP_002983671.1 510436..511077(+) (vraR) [Streptococcus pyogenes strain NCTC13737]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTGGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAGGTAGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTCTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTGTCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCTGTTGTCTACGCTTTCCGACACCATTTAGTCCCCCAAGATGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385