Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQN31_RS08590 Genome accession   NZ_LS483421
Coordinates   1709206..1711188 (-) Length   660 a.a.
NCBI ID   WP_014407935.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10877     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1704206..1716188
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN31_RS08565 (NCTC10877_01691) recA 1704242..1705378 (-) 1137 WP_014407932.1 recombinase RecA -
  DQN31_RS08570 (NCTC10877_01692) cinA 1705467..1706738 (-) 1272 WP_011285266.1 competence/damage-inducible protein A Machinery gene
  DQN31_RS08575 (NCTC10877_01693) - 1706807..1707367 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  DQN31_RS08580 (NCTC10877_01694) ruvA 1707377..1707973 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  DQN31_RS08585 (NCTC10877_01695) - 1707975..1709195 (-) 1221 WP_014407934.1 MDR family MFS transporter -
  DQN31_RS08590 (NCTC10877_01696) hexB 1709206..1711188 (-) 1983 WP_014407935.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQN31_RS08595 (NCTC10877_01697) - 1711283..1712428 (-) 1146 WP_041174352.1 tyrosine-type recombinase/integrase -
  DQN31_RS08605 (NCTC10877_01698) - 1713061..1713888 (-) 828 WP_014411910.1 hypothetical protein -
  DQN31_RS08610 (NCTC10877_01699) - 1714295..1715086 (-) 792 WP_014411911.1 helix-turn-helix domain-containing protein -
  DQN31_RS08615 (NCTC10877_01700) - 1715241..1715411 (+) 171 WP_032467166.1 helix-turn-helix transcriptional regulator -
  DQN31_RS08620 (NCTC10877_01701) - 1715466..1715873 (+) 408 WP_002992501.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74383.96 Da        Isoelectric Point: 5.8718

>NTDB_id=1024255 DQN31_RS08590 WP_014407935.1 1709206..1711188(-) (hexB) [Streptococcus pyogenes strain NCTC10877]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVKDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLVISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLNRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGDVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1024255 DQN31_RS08590 WP_014407935.1 1709206..1711188(-) (hexB) [Streptococcus pyogenes strain NCTC10877]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTAAAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAT
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGTTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGGCTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGTTGAATCGCTTGGAAAATGAAGAGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGCGACGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTCGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATCAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(462-604)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.673

Multiple sequence alignment