Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQN75_RS08580 Genome accession   NZ_LS483420
Coordinates   1702904..1704886 (-) Length   660 a.a.
NCBI ID   WP_111685305.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC13739     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1697904..1709886
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN75_RS08555 (NCTC13739_01690) recA 1697940..1699076 (-) 1137 WP_111685303.1 recombinase RecA Machinery gene
  DQN75_RS08560 (NCTC13739_01691) cinA 1699165..1700436 (-) 1272 WP_032459984.1 competence/damage-inducible protein A Machinery gene
  DQN75_RS08565 (NCTC13739_01692) - 1700505..1701065 (-) 561 WP_023611248.1 DNA-3-methyladenine glycosylase I -
  DQN75_RS08570 (NCTC13739_01693) ruvA 1701075..1701671 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA Machinery gene
  DQN75_RS08575 (NCTC13739_01694) - 1701673..1702893 (-) 1221 WP_111675058.1 MDR family MFS transporter -
  DQN75_RS08580 (NCTC13739_01695) hexB 1702904..1704886 (-) 1983 WP_111685305.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQN75_RS08585 (NCTC13739_01696) hexA 1705015..1707570 (-) 2556 WP_111685307.1 DNA mismatch repair protein MutS Machinery gene
  DQN75_RS09355 - 1707557..1707909 (-) 353 Protein_1589 YlbF family regulator -
  DQN75_RS08595 (NCTC13739_01698) argR 1707906..1708343 (-) 438 WP_002982171.1 arginine repressor -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74312.93 Da        Isoelectric Point: 5.9796

>NTDB_id=1024162 DQN75_RS08580 WP_111685305.1 1702904..1704886(-) (hexB) [Streptococcus pyogenes strain NCTC13739]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVKDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLVISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSIKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGDVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1024162 DQN75_RS08580 WP_111685305.1 1702904..1704886(-) (hexB) [Streptococcus pyogenes strain NCTC13739]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTAAAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGTTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTTTCTGAAAAAATACCTGAGACTGATTTTTATTCCGGCGCTGTTGACAACAGTATAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGGGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCATGGGACTTATCTCTTTGCTCAAGGTAAAGATGGCTTATTT
ATTATCGATCAGCATGCTGCTCAAGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGCGACGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTCGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGTATCCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(462-604)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.717

100

0.671