Detailed information    

insolico Bioinformatically predicted

Overview

Name   braR   Type   Regulator
Locus tag   DQM66_RS07685 Genome accession   NZ_LS483374
Coordinates   1462827..1463504 (-) Length   225 a.a.
NCBI ID   WP_000548959.1    Uniprot ID   Q9S1K2
Organism   Streptococcus pneumoniae strain NCTC7466     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1457827..1468504
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM66_RS07645 (NCTC7466_01473) - 1457988..1458617 (-) 630 WP_000762101.1 NAD(P)-dependent oxidoreductase -
  DQM66_RS07650 (NCTC7466_01474) - 1458856..1459056 (+) 201 WP_001826938.1 hypothetical protein -
  DQM66_RS07665 (NCTC7466_01476) - 1459487..1459627 (+) 141 WP_000422775.1 MazG-like protein -
  DQM66_RS07670 - 1459634..1459810 (+) 177 WP_000166031.1 MazG-like protein -
  DQM66_RS07675 (NCTC7466_01477) thrS 1459868..1461811 (+) 1944 WP_000608365.1 threonine--tRNA ligase -
  DQM66_RS07680 (NCTC7466_01478) - 1461860..1462834 (-) 975 WP_000887954.1 HAMP domain-containing histidine kinase -
  DQM66_RS07685 (NCTC7466_01479) braR 1462827..1463504 (-) 678 WP_000548959.1 response regulator transcription factor Regulator
  DQM66_RS07690 (NCTC7466_01480) - 1463660..1464733 (+) 1074 WP_001273825.1 DUF2974 domain-containing protein -
  DQM66_RS07695 (NCTC7466_01481) - 1464824..1465126 (-) 303 WP_000281594.1 hypothetical protein -
  DQM66_RS07700 (NCTC7466_01482) - 1465195..1465632 (-) 438 WP_001166786.1 Rrf2 family transcriptional regulator -
  DQM66_RS07705 (NCTC7466_01483) - 1465708..1466550 (-) 843 WP_000160958.1 metallophosphoesterase family protein -
  DQM66_RS07710 (NCTC7466_01484) - 1466662..1467312 (+) 651 WP_000188498.1 metal-dependent transcriptional regulator -
  DQM66_RS11510 (NCTC7466_01485) - 1467614..1468163 (+) 550 Protein_1464 nicotinamide mononucleotide transporter -

Sequence

Protein


Download         Length: 225 a.a.        Molecular weight: 25964.16 Da        Isoelectric Point: 5.1362

>NTDB_id=1021189 DQM66_RS07685 WP_000548959.1 1462827..1463504(-) (braR) [Streptococcus pneumoniae strain NCTC7466]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide


Download         Length: 678 bp        

>NTDB_id=1021189 DQM66_RS07685 WP_000548959.1 1462827..1463504(-) (braR) [Streptococcus pneumoniae strain NCTC7466]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  braR Staphylococcus aureus N315

48.624

96.889

0.471
  vicR Streptococcus mutans UA159

35.319

100

0.369