Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQL05_RS08390 Genome accession   NZ_LS483322
Coordinates   1661714..1663696 (-) Length   660 a.a.
NCBI ID   WP_002992189.1    Uniprot ID   P0DC59
Organism   Streptococcus pyogenes strain NCTC12066     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1656714..1668696
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL05_RS08365 (NCTC12066_01655) recA 1656750..1657886 (-) 1137 WP_109828910.1 recombinase RecA Machinery gene
  DQL05_RS08370 (NCTC12066_01656) cinA 1657975..1659246 (-) 1272 WP_011055089.1 competence/damage-inducible protein A Machinery gene
  DQL05_RS08375 (NCTC12066_01657) - 1659315..1659875 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  DQL05_RS08380 (NCTC12066_01658) ruvA 1659885..1660481 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  DQL05_RS08385 (NCTC12066_01659) - 1660483..1661703 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  DQL05_RS08390 (NCTC12066_01660) hexB 1661714..1663696 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQL05_RS08395 (NCTC12066_01661) - 1663791..1664942 (-) 1152 WP_172450205.1 tyrosine-type recombinase/integrase -
  DQL05_RS08400 (NCTC12066_01662) - 1665279..1666244 (-) 966 WP_065354783.1 DUF3644 domain-containing protein -
  DQL05_RS08405 - 1666404..1666508 (-) 105 Protein_1557 cell filamentation protein Fic -
  DQL05_RS08410 (NCTC12066_01663) irvR 1667534..1668301 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator Regulator
  DQL05_RS08415 (NCTC12066_01664) - 1668455..1668661 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74419.99 Da        Isoelectric Point: 5.7605

>NTDB_id=1017162 DQL05_RS08390 WP_002992189.1 1661714..1663696(-) (hexB) [Streptococcus pyogenes strain NCTC12066]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYFGTVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=1017162 DQL05_RS08390 WP_002992189.1 1661714..1663696(-) (hexB) [Streptococcus pyogenes strain NCTC12066]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAATGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAGTTGATGGCTTTAATTAGTACG
GCGATTTCTGAAAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTTCGGCACTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGAGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0DC59

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.676