Detailed information NTG1010135

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: H1X08_RS00325
• Genome accession: NZ_LR822025
• Coordinates: 55557..58115 (+)
• Length: 852 a.a.
• NCBI ID: WP_180482349.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus isolate STH_CIRM_961
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 50557..63115

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X08_RS00300 (STHERMO_0051)	purB	50770..52068 (+)	1299	WP_179972478.1	adenylosuccinate lyase	-
H1X08_RS00305 (STHERMO_0052)	-	52222..52392 (+)	171	WP_179971878.1	hypothetical protein	-
H1X08_RS00310 (STHERMO_0053)	argS	52931..54622 (-)	1692	WP_180482347.1	arginine--tRNA ligase	-
H1X08_RS00315 (STHERMO_0054)	argR	54777..55205 (+)	429	WP_024704313.1	arginine repressor	-
H1X08_RS00320 (STHERMO_0055)	-	55205..55564 (+)	360	WP_180482348.1	YlbF family regulator	-
H1X08_RS00325 (STHERMO_0056)	hexA	55557..58115 (+)	2559	WP_180482349.1	DNA mismatch repair protein MutS	Machinery gene
H1X08_RS00330 (STHERMO_0057)	-	58149..58604 (-)	456	WP_180482350.1	DUF3021 domain-containing protein	-
H1X08_RS00335	-	58601..58991 (-)	391	Protein_45	LytTR family DNA-binding domain-containing protein	-
H1X08_RS00340 (STHERMO_0059)	-	59215..59520 (+)	306	WP_180482351.1	hypothetical protein	-
H1X08_RS00345 (STHERMO_0060)	hexB	59572..61515 (+)	1944	WP_180482352.1	DNA mismatch repair endonuclease MutL	Machinery gene
H1X08_RS00350 (STHERMO_0061)	-	61646..61867 (+)	222	WP_011680602.1	hypothetical protein	-
H1X08_RS00355 (STHERMO_0062)	ruvA	62019..62609 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95426.69 Da
• Isoelectric Point: 4.6487

>NTDB_id=1010135 H1X08_RS00325 WP_180482349.1 55557..58115(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_961]
MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSCFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGMRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLAHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLIRSAIDP
DAPATITEGGIIRDGFDDTLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKVIATVDVLQSLAVTAETNHYVRPVFN
DEHRITIDQGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYIPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPEEKVSSQ
EKPAIETHVNEQIPLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=1010135 H1X08_RS00325 WP_180482349.1 55557..58115(+) (hexA) [Streptococcus thermophilus isolate STH_CIRM_961]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGAAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTGTCAAGGCTGCCCAGATTTTGGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTGAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTTGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCAAGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGGCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTAATTCAGCTAGCTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTCGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGATGGTTTTGATGATACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTACTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGTCATTGCGACAGTTGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGACAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCACTATTGATCAGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACATACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTGAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCCCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain III (MutS_III) (256-546)

• MutS domain I (MutS_I) (8-118)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.826	100	0.738
mutS	Pseudomonas stutzeri strain ATCC 17587	35.788	100	0.365