Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   H0503_RS06125 Genome accession   NZ_LR822009
Coordinates   1175394..1177181 (-) Length   595 a.a.
NCBI ID   WP_011681323.1    Uniprot ID   Q03K10
Organism   Streptococcus thermophilus isolate STH_CIRM_19     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1170394..1182181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0503_RS06105 (STHERMO_1364) - 1171358..1171998 (-) 641 Protein_1167 DNA alkylation repair protein -
  H0503_RS06110 (STHERMO_1365) - 1172190..1172702 (-) 513 WP_002951148.1 GNAT family N-acetyltransferase -
  H0503_RS10460 (STHERMO_1366) - 1172862..1172999 (+) 138 WP_170169612.1 hypothetical protein -
  H0503_RS06115 - 1172981..1173663 (+) 683 Protein_1170 ISL3 family transposase -
  H0503_RS06120 (STHERMO_1370) cls 1173755..1175305 (-) 1551 WP_179970823.1 cardiolipin synthase -
  H0503_RS06125 (STHERMO_1371) uvrC 1175394..1177181 (-) 1788 WP_011681323.1 excinuclease ABC subunit UvrC Machinery gene
  H0503_RS06130 (STHERMO_1372) - 1177241..1177936 (-) 696 WP_014608464.1 YjjG family noncanonical pyrimidine nucleotidase -
  H0503_RS06135 (STHERMO_1373) - 1178235..1178669 (+) 435 WP_049825679.1 biotin transporter BioY -
  H0503_RS06140 (STHERMO_1374) - 1178904..1179530 (-) 627 WP_014608466.1 ABC transporter permease -
  H0503_RS06145 (STHERMO_1375) - 1179535..1180290 (-) 756 WP_002948547.1 ABC transporter ATP-binding protein -
  H0503_RS06150 (STHERMO_1376) - 1180302..1181219 (-) 918 WP_179971405.1 glycine betaine ABC transporter substrate-binding protein -
  H0503_RS06155 (STHERMO_1377) - 1181216..1181875 (-) 660 WP_002948542.1 ABC transporter permease -

Sequence

Protein


Download         Length: 595 a.a.        Molecular weight: 68470.97 Da        Isoelectric Point: 9.6924

>NTDB_id=1009043 H0503_RS06125 WP_011681323.1 1175394..1177181(-) (uvrC) [Streptococcus thermophilus isolate STH_CIRM_19]
MNGLIKHKLELLPSNPGCYLHKDKFGNIIYVGKAKNLKNRVRSYFRGSHDTKTELLVSEIADFEFIVTESNIEALLLEIN
LIQENMPKFNIRLKDGKSYPFIKITKELYPRLLITRQVKKDGGLYFGPYPDSGAANEIKKLLDRIFPFKKCKNPANKVCF
YYHIGQCNAHTICHTTEDYWQGLVEDVKNFLNGHDDKIVNQLKAKMKDMSDQMAFERAAEYRDLIEAVSTLRTKQRVIRQ
DMQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYMGQFYLDSRHLKPKEIFIPGDIDQESVEAL
VGDEVKVFKPKRGEKKQLVNLATKNARVSLTQKFDLLEKDIAKTQGAIENLGKLMGIPTPVRIESFDNSNIMGTSPVSAM
VVFENGKPNKKEYRKYKIKTVEGPDDYASMREVIRRRYSRVKRDGLTPPDLIIMDGGQGQVNVAKDVLRNELNLSIPVAG
LQKNDKHQTNELLFGDPLRVIDLPRQSEEFFLLHRIQDEVHRFAITFHRQVRSKNSFSSKLDGVEGLGPKRKQKLLKNFK
SMTAIQQASVEDIQALGIPKKVAQALLDKLSQDSH

Nucleotide


Download         Length: 1788 bp        

>NTDB_id=1009043 H0503_RS06125 WP_011681323.1 1175394..1177181(-) (uvrC) [Streptococcus thermophilus isolate STH_CIRM_19]
ATGAATGGTCTGATTAAACATAAGTTGGAACTGCTCCCAAGCAACCCAGGGTGTTATCTCCACAAGGACAAATTCGGCAA
TATTATTTATGTCGGTAAGGCTAAAAATCTAAAAAATCGTGTGCGTAGCTATTTTCGTGGAAGCCATGATACCAAGACGG
AGCTTTTGGTATCTGAGATTGCAGACTTTGAATTTATCGTAACCGAGTCTAATATCGAGGCCCTGCTTTTGGAAATTAAC
CTCATTCAAGAGAATATGCCCAAATTTAACATTCGCCTCAAGGATGGCAAGTCTTATCCATTTATCAAGATTACTAAGGA
ACTCTATCCAAGGCTCTTGATTACCCGCCAGGTTAAGAAGGATGGTGGTCTCTATTTTGGTCCTTACCCAGACTCTGGTG
CAGCCAATGAAATCAAGAAGCTGTTGGACCGTATTTTCCCCTTTAAGAAATGTAAAAATCCTGCTAACAAGGTCTGTTTC
TATTACCATATTGGCCAATGTAATGCCCACACCATCTGTCACACCACTGAGGACTATTGGCAAGGTTTGGTTGAGGATGT
CAAGAATTTTCTAAACGGTCATGATGATAAAATCGTTAACCAGCTTAAGGCCAAGATGAAGGACATGTCTGATCAGATGG
CGTTTGAGCGGGCAGCAGAATATCGAGATCTGATTGAGGCAGTGTCGACGCTCAGGACCAAACAAAGGGTTATCCGTCAA
GATATGCAGGACCGCGATATTTTTGGCTACTACGTGGACAAGGGCTGGATGTGTGTTCAAGTTTTCTTTGTTCGCCAAGG
AAAACTCATCCAGCGTGATGTCAATATGTTCCCTTACTATAATGATGCTGAGGAAGATTTTCTAACCTATATGGGTCAAT
TTTACTTGGATAGCCGTCATCTCAAGCCTAAGGAGATTTTCATTCCAGGGGACATTGATCAAGAGTCTGTCGAAGCTCTG
GTCGGAGATGAAGTCAAGGTTTTTAAACCGAAAAGAGGCGAGAAAAAGCAGTTGGTTAATCTGGCAACGAAAAATGCCCG
TGTCAGCCTGACTCAAAAATTTGATCTTCTTGAAAAAGATATAGCCAAGACCCAAGGAGCCATTGAAAATCTAGGCAAAC
TCATGGGAATTCCGACACCGGTTCGCATCGAGTCCTTCGATAACTCTAACATCATGGGAACGAGCCCTGTATCTGCCATG
GTCGTTTTTGAGAACGGCAAACCTAATAAAAAAGAGTACCGCAAATACAAGATTAAGACGGTTGAAGGTCCTGACGATTA
TGCCAGCATGCGTGAGGTCATTCGTCGCCGTTATAGTCGTGTCAAACGTGATGGTCTAACCCCACCAGACCTCATTATCA
TGGATGGTGGTCAAGGTCAGGTCAATGTCGCTAAGGACGTGCTTCGTAATGAGCTGAATCTATCTATCCCGGTTGCAGGT
CTTCAGAAAAATGACAAGCACCAAACCAATGAATTGCTCTTTGGAGATCCTTTGCGAGTCATTGATTTGCCACGTCAATC
CGAGGAGTTTTTCCTCCTTCACCGTATTCAGGATGAAGTACACCGCTTTGCCATCACCTTCCATCGACAAGTCCGTAGTA
AGAATAGTTTCAGTTCCAAACTTGATGGCGTGGAGGGGTTGGGACCTAAACGCAAACAAAAACTCCTCAAAAACTTCAAA
TCAATGACAGCTATCCAACAAGCCAGTGTCGAAGACATCCAAGCTCTTGGAATTCCTAAAAAAGTAGCTCAAGCTTTATT
AGATAAGTTGAGCCAAGATAGTCATTAA

Domains

Predicted by InterProScan.

GIY-YIG catalytic domain (GIY-YIG)

(16-87)

UvrB/uvrC motif (UVR)

(196-229)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(375-525)

Helix-hairpin-helix domain (HHH_5)

(540-590)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03K10

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

75.804

99.328

0.753
  uvrC Streptococcus pneumoniae R6

75.465

99.328

0.75
  uvrC Streptococcus pneumoniae D39

75.465

99.328

0.75

Multiple sequence alignment