Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   UXQ45_RS00365 Genome accession   NZ_CP157420
Coordinates   77849..79198 (-) Length   449 a.a.
NCBI ID   WP_000815646.1    Uniprot ID   Q9XB96
Organism   Staphylococcus aureus strain BSN48-2     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39658..79198 77849..79198 within 0


Gene organization within MGE regions


Location: 39658..79198
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UXQ45_RS00180 (UXQ45_000180) ccrB 39658..41286 (-) 1629 WP_001631035.1 recombinase family protein Machinery gene
  UXQ45_RS00185 (UXQ45_000185) ccrA 41283..42644 (-) 1362 WP_001631036.1 recombinase family protein Machinery gene
  UXQ45_RS00190 (UXQ45_000190) - 42831..43460 (-) 630 Protein_35 hypothetical protein -
  UXQ45_RS00195 (UXQ45_000195) - 43469..43807 (+) 339 Protein_36 recombinase family protein -
  UXQ45_RS00200 (UXQ45_000200) - 43919..44278 (-) 360 WP_001631039.1 hypothetical protein -
  UXQ45_RS00205 (UXQ45_000205) - 44485..44811 (+) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  UXQ45_RS00210 (UXQ45_000210) - 45141..47066 (+) 1926 WP_304690359.1 heavy metal translocating P-type ATPase -
  UXQ45_RS00215 (UXQ45_000215) - 48292..49548 (+) 1257 WP_000566670.1 DUF3578 domain-containing protein -
  UXQ45_RS00220 (UXQ45_000220) - 49963..50202 (+) 240 WP_001282728.1 hypothetical protein -
  UXQ45_RS00225 (UXQ45_000225) - 50234..50908 (-) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  UXQ45_RS00230 (UXQ45_000230) - 50999..51982 (-) 984 Protein_43 protein rep -
  UXQ45_RS00235 (UXQ45_000235) mobV 52227..53489 (-) 1263 WP_000119405.1 MobV family relaxase -
  UXQ45_RS00240 (UXQ45_000240) bleO 53996..54400 (-) 405 WP_001242578.1 bleomycin binding protein -
  UXQ45_RS00245 (UXQ45_000245) aadD1 54617..55387 (-) 771 WP_001795128.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  UXQ45_RS00250 (UXQ45_000250) - 55580..56254 (-) 675 WP_349427128.1 IS6-like element IS257 family transposase -
  UXQ45_RS00255 (UXQ45_000255) - 56519..57262 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  UXQ45_RS00260 (UXQ45_000260) - 57359..57787 (+) 429 WP_000872606.1 MaoC family dehydratase -
  UXQ45_RS00265 (UXQ45_000265) mecA 57833..59842 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  UXQ45_RS00270 (UXQ45_000270) mecR1 59939..61696 (+) 1758 WP_304707293.1 beta-lactam sensor/signal transducer MecR1 -
  UXQ45_RS00275 (UXQ45_000275) mecI 61696..62067 (+) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  UXQ45_RS00280 (UXQ45_000280) psm-mec 62152..62220 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  UXQ45_RS00285 (UXQ45_000285) - 62554..63684 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  UXQ45_RS00290 (UXQ45_000290) cstB 63798..65132 (-) 1335 Protein_55 persulfide dioxygenase-sulfurtransferase CstB -
  UXQ45_RS00295 (UXQ45_000295) - 65165..66229 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  UXQ45_RS00300 (UXQ45_000300) cstR 66365..66625 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  UXQ45_RS00305 (UXQ45_000305) - 66625..67263 (+) 639 Protein_58 sulfite exporter TauE/SafE family protein -
  UXQ45_RS00310 (UXQ45_000310) - 67608..68270 (-) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  UXQ45_RS00315 (UXQ45_000315) erm(A) 68804..69535 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  UXQ45_RS00320 (UXQ45_000320) - 69661..70443 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  UXQ45_RS00325 (UXQ45_000325) - 70594..70971 (-) 378 WP_000361059.1 DUF6262 family protein -
  UXQ45_RS00330 (UXQ45_000330) - 70978..72870 (-) 1893 WP_001557544.1 site-specific integrase -
  UXQ45_RS00335 (UXQ45_000335) - 72867..73952 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  UXQ45_RS00340 (UXQ45_000340) - 74071..74388 (-) 318 WP_000659050.1 JAB domain-containing protein -
  UXQ45_RS00345 (UXQ45_000345) - 74409..74915 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  UXQ45_RS00350 (UXQ45_000350) - 74933..75244 (-) 312 WP_000700853.1 DUF960 family protein -
  UXQ45_RS00355 (UXQ45_000355) - 75331..75681 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  UXQ45_RS00360 (UXQ45_000360) ccrB 76199..77827 (-) 1629 WP_001186602.1 recombinase family protein Machinery gene
  UXQ45_RS00365 (UXQ45_000365) ccrA 77849..79198 (-) 1350 WP_000815646.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52607.20 Da        Isoelectric Point: 9.9585

>NTDB_id=1006701 UXQ45_RS00365 WP_000815646.1 77849..79198(-) (ccrA) [Staphylococcus aureus strain BSN48-2]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1006701 UXQ45_RS00365 WP_000815646.1 77849..79198(-) (ccrA) [Staphylococcus aureus strain BSN48-2]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

100

100

1
  ccrA Staphylococcus aureus COL

74.833

100

0.748

Multiple sequence alignment