Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   E0F31_RS00915 Genome accession   NZ_LR216064
Coordinates   158000..159949 (+) Length   649 a.a.
NCBI ID   WP_054363032.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 153000..164949
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS00880 (SAMEA3714520_00159) - 153803..154336 (+) 534 WP_000729029.1 hypothetical protein -
  E0F31_RS00885 (SAMEA3714520_00160) nrdI 154414..154884 (+) 471 WP_000849621.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  E0F31_RS00895 (SAMEA3714520_00161) - 155177..156439 (-) 1263 WP_000075789.1 NRAMP family divalent metal transporter -
  E0F31_RS00900 (SAMEA3714520_00162) - 156749..157207 (-) 459 WP_000745053.1 DUF3021 domain-containing protein -
  E0F31_RS00905 (SAMEA3714520_00163) brsR 157204..157644 (-) 441 WP_000861958.1 LytTR family DNA-binding domain-containing protein Regulator
  E0F31_RS12010 - 157732..157857 (-) 126 WP_001822433.1 hypothetical protein -
  E0F31_RS00915 (SAMEA3714520_00164) hexB 158000..159949 (+) 1950 WP_054363032.1 DNA mismatch repair endonuclease MutL Machinery gene
  E0F31_RS00920 (SAMEA3714520_00165) ribE 160274..160741 (-) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  E0F31_RS00925 (SAMEA3714520_00166) - 160742..161947 (-) 1206 WP_001839250.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  E0F31_RS00930 (SAMEA3714520_00167) ribE 161967..162602 (-) 636 WP_000493842.1 riboflavin synthase -
  E0F31_RS00935 (SAMEA3714520_00168) ribD 162587..163687 (-) 1101 WP_001284096.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  E0F31_RS00940 (SAMEA3714520_00169) ruvA 164091..164684 (+) 594 WP_000271493.1 Holliday junction branch migration protein RuvA Machinery gene

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73446.90 Da        Isoelectric Point: 5.2350

>NTDB_id=1003935 E0F31_RS00915 WP_054363032.1 158000..159949(+) (hexB) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGYGISHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSAVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=1003935 E0F31_RS00915 WP_054363032.1 158000..159949(+) (hexB) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCAGCTGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AGGTTCAAATCACAGATAACGGTTATGGAATTTCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGTGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCTTTACCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTCGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACCCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGGCCGTGCGCAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGTCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

99.538

100

0.995