Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EL070_RS03020 Genome accession   NZ_LR134284
Coordinates   567126..567767 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain NCTC8232     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 562126..572767
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL070_RS03000 (NCTC8232_00596) - 562682..563422 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  EL070_RS03005 (NCTC8232_00597) pknB 563419..565317 (+) 1899 WP_011888669.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EL070_RS03010 (NCTC8232_00598) liaF 565440..566132 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  EL070_RS03015 (NCTC8232_00599) - 566129..567133 (+) 1005 WP_011528855.1 sensor histidine kinase -
  EL070_RS03020 (NCTC8232_00600) vraR 567126..567767 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  EL070_RS03025 (NCTC8232_00601) - 567804..569204 (+) 1401 WP_111705724.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EL070_RS03030 (NCTC8232_00602) - 569204..569581 (+) 378 WP_111705723.1 S1 RNA-binding domain-containing protein -
  EL070_RS03035 (NCTC8232_00603) cysK 569599..570540 (-) 942 WP_111705722.1 cysteine synthase A -
  EL070_RS03040 (NCTC8232_00604) - 570668..571300 (-) 633 WP_111705721.1 YigZ family protein -
  EL070_RS03045 (NCTC8232_00605) comFA/cflA 571356..572681 (+) 1326 WP_111705720.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=1000022 EL070_RS03020 WP_002983671.1 567126..567767(+) (vraR) [Streptococcus pyogenes strain NCTC8232]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=1000022 EL070_RS03020 WP_002983671.1 567126..567767(+) (vraR) [Streptococcus pyogenes strain NCTC8232]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTGTCAAAGGGAGAGCTAGCCATTGAAACAGAGGTAGACAAAA
AAATTAAAGCGCATGACCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385