Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 29755..30374 | Replicon | plasmid pA |
| Accession | NZ_CP019513 | ||
| Organism | Enterococcus faecalis strain CLB21560 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | R3H4V2 |
| Locus tag | BZG32_RS16395 | Protein ID | WP_000241511.1 |
| Coordinates | 30012..30374 (+) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | R3H5D1 |
| Locus tag | BZG32_RS16390 | Protein ID | WP_000245205.1 |
| Coordinates | 29755..30018 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - | 25247..25349 | + | 103 | NuclAT_0 | - | - |
| - | 25247..25349 | + | 103 | NuclAT_0 | - | - |
| - | 25247..25349 | + | 103 | NuclAT_0 | - | - |
| - | 25247..25349 | + | 103 | NuclAT_0 | - | - |
| BZG32_RS16345 | 25389..25499 | - | 111 | WP_107164701.1 | type I toxin-antitoxin system Fst family toxin | - |
| BZG32_RS16355 | 25750..26100 | - | 351 | WP_002365943.1 | hypothetical protein | - |
| BZG32_RS16360 | 26097..27425 | - | 1329 | WP_002387639.1 | Y-family DNA polymerase | - |
| BZG32_RS16365 | 27852..28154 | - | 303 | WP_002365939.1 | hypothetical protein | - |
| BZG32_RS16370 | 28166..28375 | - | 210 | WP_002387638.1 | hypothetical protein | - |
| BZG32_RS16375 | 28436..28660 | - | 225 | WP_010708492.1 | hypothetical protein | - |
| BZG32_RS16380 | 28654..28941 | - | 288 | WP_010708491.1 | hypothetical protein | - |
| BZG32_RS16385 | 28958..29578 | - | 621 | WP_021732893.1 | recombinase family protein | - |
| BZG32_RS16390 | 29755..30018 | + | 264 | WP_000245205.1 | PbsX family transcriptional regulator | Antitoxin |
| BZG32_RS16395 | 30012..30374 | + | 363 | WP_000241511.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| BZG32_RS16400 | 30439..31401 | - | 963 | WP_002367770.1 | LacI family DNA-binding transcriptional regulator | - |
| BZG32_RS16405 | 31403..32842 | - | 1440 | WP_002367771.1 | sucrose-6-phosphate hydrolase | - |
| BZG32_RS16410 | 33033..34964 | + | 1932 | WP_002370258.1 | sucrose-specific PTS transporter subunit IIBC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | aac(6')-aph(2'') / qacZ / dfrG | asa1 | 1..66602 | 66602 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13585.78 Da Isoelectric Point: 9.6107
>T72615 WP_000241511.1 NZ_CP019513:30012-30374 [Enterococcus faecalis]
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
Download Length: 363 bp
>T72615 NZ_CP019513:30012-30374 [Enterococcus faecalis]
ATGGTAAAAGTTCCTCATCAAGGTGATATTTTATTGTTGAATACGGCTCCTAGATCAGGACATGAACAAACAGGTAAGAG
ACCGTATATTGTTTTAAGTCATGATATTATTGCAGATTACAGCAATGTTGTTATTGTAGCTCCTATATCAAGTACAAAAA
GAAACTATCCTTTATATGTTTCTATTAATCCTTCTTACGGAATGAAAACATCAGGTAAAGTATTATTAGATCAATTAACC
ACCATCGATTATGAGGCTAGACAATGCGTGTTTTTAGAAACAGCACACGAAAAATTAATCGATGAATTATTGCTAAAAGT
TAGAACCGTATTTCAAAAAGTAAATAAAACAAATAAATTTTAA
ATGGTAAAAGTTCCTCATCAAGGTGATATTTTATTGTTGAATACGGCTCCTAGATCAGGACATGAACAAACAGGTAAGAG
ACCGTATATTGTTTTAAGTCATGATATTATTGCAGATTACAGCAATGTTGTTATTGTAGCTCCTATATCAAGTACAAAAA
GAAACTATCCTTTATATGTTTCTATTAATCCTTCTTACGGAATGAAAACATCAGGTAAAGTATTATTAGATCAATTAACC
ACCATCGATTATGAGGCTAGACAATGCGTGTTTTTAGAAACAGCACACGAAAAATTAATCGATGAATTATTGCTAAAAGT
TAGAACCGTATTTCAAAAAGTAAATAAAACAAATAAATTTTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10059.46 Da Isoelectric Point: 5.1585
>AT72615 WP_000245205.1 NZ_CP019513:29755-30018 [Enterococcus faecalis]
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
Download Length: 264 bp
>AT72615 NZ_CP019513:29755-30018 [Enterococcus faecalis]
ATGGTAATGTTATCAATAAAAAAATGGGGCAATAGTAACGGTCTTAGACTTCCTAAATCTGTGATGGAATATCTCCAAAT
TCATACAGAAGATAAAGTGAAAATAACACAGGAGGAATCGAATGGTAAAAAACGATTAATTATTGAAGCTGTGGATTCTG
ATAATGATTTAACAATTGAACAATTGTTTGAAAATTATAAAGAAGAGAAGGTGCATGTAACTATTCAAGATTTAGGAAAT
GCGGTAGGAAATGAAAAATGGTAA
ATGGTAATGTTATCAATAAAAAAATGGGGCAATAGTAACGGTCTTAGACTTCCTAAATCTGTGATGGAATATCTCCAAAT
TCATACAGAAGATAAAGTGAAAATAACACAGGAGGAATCGAATGGTAAAAAACGATTAATTATTGAAGCTGTGGATTCTG
ATAATGATTTAACAATTGAACAATTGTTTGAAAATTATAAAGAAGAGAAGGTGCATGTAACTATTCAAGATTTAGGAAAT
GCGGTAGGAAATGAAAAATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|