Detailed information of TA system TA006372

Experimentally validated

Overview

TA module

• Type: III
• Classification (family/domain): cptIN/-
• Location: 1041363..1041950
• Replicon: draft genome
• Accession: NC_021009
• Organism: Coprococcus catus GD/7

Toxin (Protein)

• Gene name: cptN
• Uniprot ID: -
• Locus tag: CC1_10040
• Protein ID: WP_015513411.1
• Coordinates: 1041468..1041950 (+)
• Length: 161 a.a.

Antitoxin (RNA)

Gene name	cptI
Locus tag	-
Coordinates	1041363..1041408 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CC1_RS04720 (CC1_09990)	1036719..1037678	+	960	WP_015513407.1	hypothetical protein	-
CC1_RS04725 (CC1_10000)	1037663..1037863	+	201	WP_015513408.1	hypothetical protein	-
CC1_RS04730	1037832..1038434	+	603	Protein_942	Fic family protein	-
CC1_RS04735 (CC1_10020)	1038529..1038861	+	333	WP_015513409.1	nucleotide pyrophosphohydrolase	-
CC1_RS04740 (CC1_10030)	1038879..1040678	+	1800	WP_208728540.1	DUF2075 domain-containing protein	-
-	1041363..1041408	+	46	-	-	Antitoxin
CC1_RS04745 (CC1_10040)	1041468..1041950	+	483	WP_015513411.1	hypothetical protein	Toxin
CC1_RS04750	1042111..1042341	+	231	WP_117529233.1	hypothetical protein	-
CC1_RS04755 (CC1_10060)	1042908..1043393	+	486	WP_015513412.1	low molecular weight protein-tyrosine-phosphatase	-
CC1_RS04760	1043547..1043747	+	201	WP_117529097.1	hypothetical protein	-
CC1_RS04765 (CC1_10080)	1043964..1045415	+	1452	WP_015513413.1	NAD(P)/FAD-dependent oxidoreductase	-
CC1_RS04770 (CC1_10090)	1045427..1046689	+	1263	WP_015513414.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 18928.94 Da
• Isoelectric Point: 8.2306

>T6372 WP_015513411.1 NC_021009:1041468-1041950 [Coprococcus catus GD/7]
MEIGHFYYIDDQYFKDFPDSYLMQNKEKVNGQLHDRPCFYAFQDSNTQLFWMIPFSSQTSKFKGIYNKKMQKYHRCDTIV
FGEVLGHEKAFLIQNMCPITEKYMKNEYLDAVANIPVRVDGRLEKEIKDKAGKVLALQRKGAKLIFPDVLSIEQELLKYM

Nucleotide

• Length: 483 bp

>T6372 NC_021009:1041468-1041950 [Coprococcus catus GD/7]
ATGGAAATAGGACATTTTTATTATATTGATGATCAATACTTTAAGGATTTTCCAGATTCTTATTTGATGCAGAATAAGGA
AAAGGTAAATGGACAGTTACATGATAGACCATGCTTTTACGCATTCCAGGATAGTAATACGCAGCTGTTTTGGATGATAC
CATTTTCATCACAGACCTCTAAATTTAAAGGAATCTATAATAAGAAAATGCAAAAGTATCATAGGTGCGATACAATTGTT
TTTGGAGAAGTGCTTGGTCATGAGAAGGCATTTTTGATTCAAAATATGTGCCCGATTACAGAAAAATATATGAAAAATGA
GTATCTGGACGCTGTTGCCAATATACCAGTTCGTGTTGATGGTAGATTGGAAAAGGAGATAAAGGATAAAGCAGGAAAAG
TTTTAGCATTGCAGAGAAAGGGAGCGAAGTTGATTTTTCCAGATGTCCTTAGTATAGAACAGGAATTATTAAAATATATG
TAA

Antitoxin

Nucleotide

• Length: 46 bp

>AT6372 NC_021009:1041363-1041408 [Coprococcus catus GD/7]
CAAATGTTTGTCGCTACTCGATATGCGACTTAGAAAAGGTCGAGTT

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
T6373	Ruminococcus torques L2-14	43.506	96.25	0.419
T6374	Eubacterium rectale DSM 17629	39.355	96.875	0.381

Multiple sequence alignment

Structures

Antitoxin

References

(1) Tim R Blower et al. (2012) Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic Acids Research 40(13):6158-73. [PubMed:22434880]


 experimental literature