Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Xre-RelE |
| Location | 194764..195356 | Replicon | plasmid Rts1 |
| Accession | NC_003905 | ||
| Organism | Proteus vulgaris | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q7A225 |
| Locus tag | HXF74_RS01175 | Protein ID | WP_011039853.1 |
| Coordinates | 194764..195042 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | L7Z874 |
| Locus tag | HXF74_RS01180 | Protein ID | WP_011039854.1 |
| Coordinates | 195042..195356 (+) | Length | 105 a.a. |
Genomic Context
Location: 190571..191479 (909 bp)
Type: Others
Protein ID: WP_011039846.1
Type: Others
Protein ID: WP_011039846.1
Location: 191765..192094 (330 bp)
Type: Others
Protein ID: WP_011039848.1
Type: Others
Protein ID: WP_011039848.1
Location: 192091..192543 (453 bp)
Type: Others
Protein ID: WP_109910770.1
Type: Others
Protein ID: WP_109910770.1
Location: 193584..193826 (243 bp)
Type: Others
Protein ID: WP_011039851.1
Type: Others
Protein ID: WP_011039851.1
Location: 194270..194593 (324 bp)
Type: Others
Protein ID: WP_109910769.1
Type: Others
Protein ID: WP_109910769.1
Location: 194764..195042 (279 bp)
Type: Toxin
Protein ID: WP_011039853.1
Type: Toxin
Protein ID: WP_011039853.1
Location: 195042..195356 (315 bp)
Type: Antitoxin
Protein ID: WP_011039854.1
Type: Antitoxin
Protein ID: WP_011039854.1
Location: 195594..195983 (390 bp)
Type: Others
Protein ID: WP_172691635.1
Type: Others
Protein ID: WP_172691635.1
Location: 196183..197103 (921 bp)
Type: Others
Protein ID: WP_011039857.1
Type: Others
Protein ID: WP_011039857.1
Location: 197135..197311 (177 bp)
Type: Others
Protein ID: WP_011039858.1
Type: Others
Protein ID: WP_011039858.1
Location: 197337..197774 (438 bp)
Type: Others
Protein ID: WP_109910766.1
Type: Others
Protein ID: WP_109910766.1
Location: 197792..198514 (723 bp)
Type: Others
Protein ID: WP_109910765.1
Type: Others
Protein ID: WP_109910765.1
Location: 198794..199309 (516 bp)
Type: Others
Protein ID: WP_109910764.1
Type: Others
Protein ID: WP_109910764.1
Location: 199617..199931 (315 bp)
Type: Others
Protein ID: WP_109910763.1
Type: Others
Protein ID: WP_109910763.1
Location: 196014..196184 (171 bp)
Type: Others
Protein ID: WP_176455176.1
Type: Others
Protein ID: WP_176455176.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HXF74_RS01150 (Rts1_253) | 190571..191479 | + | 909 | WP_011039846.1 | hypothetical protein | - |
| HXF74_RS01155 (Rts1_255) | 191765..192094 | + | 330 | WP_011039848.1 | hypothetical protein | - |
| HXF74_RS01160 (Rts1_256) | 192091..192543 | + | 453 | WP_109910770.1 | hypothetical protein | - |
| HXF74_RS01165 (Rts1_258) | 193584..193826 | + | 243 | WP_011039851.1 | hypothetical protein | - |
| HXF74_RS01170 (Rts1_259) | 194270..194593 | + | 324 | WP_109910769.1 | hypothetical protein | - |
| HXF74_RS01175 (Rts1_260) | 194764..195042 | + | 279 | WP_011039853.1 | type II toxin-antitoxin system toxin endoribonuclease HigB | Toxin |
| HXF74_RS01180 (Rts1_261) | 195042..195356 | + | 315 | WP_011039854.1 | type II toxin antitoxin system addiction module antidote protein HigA | Antitoxin |
| HXF74_RS01185 (Rts1_262) | 195594..195983 | + | 390 | WP_172691635.1 | hypothetical protein | - |
| HXF74_RS01190 | 196014..196184 | - | 171 | WP_176455176.1 | hypothetical protein | - |
| HXF74_RS01195 (Rts1_264) | 196183..197103 | + | 921 | WP_011039857.1 | hypothetical protein | - |
| HXF74_RS01200 (Rts1_265) | 197135..197311 | + | 177 | WP_011039858.1 | hypothetical protein | - |
| HXF74_RS01205 (Rts1_266) | 197337..197774 | + | 438 | WP_109910766.1 | plasmid protein | - |
| HXF74_RS01210 (Rts1_267) | 197792..198514 | + | 723 | WP_109910765.1 | hypothetical protein | - |
| HXF74_RS01215 (Rts1_268) | 198794..199309 | + | 516 | WP_109910764.1 | hypothetical protein | - |
| HXF74_RS01220 | 199617..199931 | + | 315 | WP_109910763.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-Ia | - | 1..217182 | 217182 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10742.22 Da Isoelectric Point: 8.4392
>T6146 WP_011039853.1 NC_003905:194764-195042 [Proteus vulgaris]
MIKSFKHKGLKLLFEKGVTSGVPAQDVDRINDRLQAIDTATEIGELNRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH
MIKSFKHKGLKLLFEKGVTSGVPAQDVDRINDRLQAIDTATEIGELNRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH
Download Length: 279 bp
>T6146 NC_003905:194764-195042 [Proteus vulgaris]
ATGATAAAATCTTTCAAGCACAAAGGATTGAAACTGCTTTTTGAAAAGGGTGTTACTTCTGGTGTGCCTGCGCAAGATGT
AGACAGAATCAATGACCGTTTGCAGGCCATCGATACAGCGACAGAGATTGGTGAACTAAACCGCCAGATTTACAAATTAC
ATCCATTAAAGGGGGATCGGGAAGGTTACTGGTCTATCACTGTCCGGGCGAATTGGCGCATTACTTTTCAGTTCATTAAC
GGTGATGCTTACATTTTAAATTATGAGGATTATCACTAA
ATGATAAAATCTTTCAAGCACAAAGGATTGAAACTGCTTTTTGAAAAGGGTGTTACTTCTGGTGTGCCTGCGCAAGATGT
AGACAGAATCAATGACCGTTTGCAGGCCATCGATACAGCGACAGAGATTGGTGAACTAAACCGCCAGATTTACAAATTAC
ATCCATTAAAGGGGGATCGGGAAGGTTACTGGTCTATCACTGTCCGGGCGAATTGGCGCATTACTTTTCAGTTCATTAAC
GGTGATGCTTACATTTTAAATTATGAGGATTATCACTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11536.99 Da Isoelectric Point: 6.7241
>AT6146 WP_011039854.1 NC_003905:195042-195356 [Proteus vulgaris]
MRQFKVSHPGEMIARDLEDMGVSGRRFAHNIGVTPATVSRLLAGKTALTPSLSIRIAAALGSTPEFWLRLQSNYDLRQLE
NQIDTSGIVLYGESNEQQQNAQEH
MRQFKVSHPGEMIARDLEDMGVSGRRFAHNIGVTPATVSRLLAGKTALTPSLSIRIAAALGSTPEFWLRLQSNYDLRQLE
NQIDTSGIVLYGESNEQQQNAQEH
Download Length: 315 bp
>AT6146 NC_003905:195042-195356 [Proteus vulgaris]
ATGAGACAATTCAAGGTTTCACATCCGGGTGAGATGATAGCCCGCGATTTAGAGGATATGGGAGTGAGTGGTCGTCGTTT
TGCTCACAATATTGGTGTTACACCAGCAACCGTATCCCGTCTACTTGCGGGGAAAACTGCGTTGACCCCTTCTCTTTCGA
TTCGTATTGCTGCGGCACTGGGGAGTACGCCTGAGTTTTGGTTACGGCTACAGAGCAATTATGATCTGCGCCAGTTAGAA
AACCAAATCGATACATCCGGGATCGTCTTGTACGGTGAGTCGAACGAACAGCAGCAGAACGCGCAAGAGCATTAA
ATGAGACAATTCAAGGTTTCACATCCGGGTGAGATGATAGCCCGCGATTTAGAGGATATGGGAGTGAGTGGTCGTCGTTT
TGCTCACAATATTGGTGTTACACCAGCAACCGTATCCCGTCTACTTGCGGGGAAAACTGCGTTGACCCCTTCTCTTTCGA
TTCGTATTGCTGCGGCACTGGGGAGTACGCCTGAGTTTTGGTTACGGCTACAGAGCAATTATGATCTGCGCCAGTTAGAA
AACCAAATCGATACATCCGGGATCGTCTTGTACGGTGAGTCGAACGAACAGCAGCAGAACGCGCAAGAGCATTAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6083 | Pseudomonas putida KT2440 | 30.851 | 100 | 0.315 |
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Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT171 | Vibrio cholerae O1 biovar El Tor str. N16961 | 44.595 | 71.154 | 0.317 |
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Multiple sequence alignment
References
(1) Jennifer M Hurley et al. (2009) Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. The Journal of Biological Chemistry 284(28):18605-13. [PubMed:19423702]
(2) Marc A Schureck et al. (2019) Structural basis of transcriptional regulation by the HigA antitoxin. Molecular Microbiology 111(6):1449-1462. [PubMed:30793388]