Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Xre-RelE |
| Location | 4241636..4242238 | Replicon | chromosome |
| Accession | NC_003197 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | C0Q3J8 |
| Locus tag | STM4032.2N | Protein ID | WP_001159630.1 |
| Coordinates | 4241649..4241957 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | STM4033 | Protein ID | NP_462913.3 |
| Coordinates | 4241997..4242251 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STM4026 | 4236762..4237361 | + | 600 | NP_462906.1 | putative enzyme | - |
| STM4027 | 4237355..4238227 | + | 873 | NP_462907.1 | tRNA processing exoribonuclease BN | - |
| STM4028 | 4238224..4238661 | + | 438 | NP_462908.1 | D-Tyr-tRNA(Tyr) deacylase | - |
| STM4029 | 4238658..4239647 | + | 990 | NP_462909.1 | putative acetyltransferase | - |
| STM4030 | 4239662..4240108 | - | 447 | NP_462910.3 | putative cytoplasmic protein | - |
| STM4031 | 4240105..4240416 | - | 312 | NP_462911.1 | putative cytoplasmic protein | - |
| STM4032 | 4240502..4241431 | - | 930 | NP_462912.1 | putative acetyl esterase | - |
| - | 4241649..4241957 | + | 309 | - | - | Toxin |
| STM4033 | 4241997..4242251 | + | 255 | NP_462913.3 | putative merR family bacterial regulatory protein | Antitoxin |
| STM4034 | 4242298..4243227 | - | 930 | NP_462914.1 | putative formate dehydrogenase formation protein | - |
| STM4035 | 4243224..4243859 | - | 636 | NP_462915.1 | formate dehydrogenase, cytochrome B556 (FDO) subunit | - |
| STM4036 | 4243856..4244758 | - | 903 | NP_462916.1 | formate dehydrogenase-O, Fe-S subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T6088 WP_001159630.1 NC_003197:4241649-4241957 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 309 bp
>T6088 NC_003197:4241649-4241957 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGG
Antitoxin
Download Length: 85 a.a. Molecular weight: 9522.89 Da Isoelectric Point: 10.7969
>AT6088 NP_462913.3 NC_003197:4241997-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALLRAIANDPRNVIQ
ALRY
MSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALLRAIANDPRNVIQ
ALRY
Download Length: 255 bp
>AT6088 NC_003197:4241997-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTCTCGTACCTTTCATATTGATGCAATGAAGATTAAAGA
AATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGCTGATTTCGGTCAACGTGGATACGCTGCGCAACTGGG
AGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTTCGCGCCATTGCCAACGACCCGAGAAACGTTATACAA
GCATTGCGTTATTGA
ATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTCTCGTACCTTTCATATTGATGCAATGAAGATTAAAGA
AATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGCTGATTTCGGTCAACGTGGATACGCTGCGCAACTGGG
AGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTTCGCGCCATTGCCAACGACCCGAGAAACGTTATACAA
GCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T303 | Pseudomonas putida KT2440 |
56.311 |
100 |
0.563 |
| T174 | Vibrio cholerae O1 biovar El Tor str. N16961 |
40.594 |
98.058 |
0.398 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT303 | Pseudomonas putida KT2440 |
65.854 |
97.619 |
0.643 |
Multiple sequence alignment
References
(1) Miguel A De la Cruz et al. (2013) A toxin-antitoxin module of Salmonella promotes virulence in mice. PLoS Pathogens 9(12):e1003827. [PubMed:24385907]