Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Xre-RelE
Location 4241636..4242238 Replicon chromosome
Accession NC_003197
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag STM4032.2N Protein ID WP_001159630.1
Coordinates 4241649..4241957 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag STM4033 Protein ID NP_462913.3
Coordinates 4241997..4242251 (+) Length 85 a.a.

Genomic Context

STM4026STM4027STM4028STM4029-STM4033STM4030STM4031STM4032STM4034STM4035STM4036
Location: 4236762..4237361 (600 bp)
Type: Others
Protein ID: NP_462906.1
Location: 4237355..4238227 (873 bp)
Type: Others
Protein ID: NP_462907.1
Location: 4238224..4238661 (438 bp)
Type: Others
Protein ID: NP_462908.1
Location: 4238658..4239647 (990 bp)
Type: Others
Protein ID: NP_462909.1
Location: 4241649..4241957 (309 bp)
Type: Toxin
Protein ID: -
Location: 4241997..4242251 (255 bp)
Type: Antitoxin
Protein ID: NP_462913.3
Location: 4239662..4240108 (447 bp)
Type: Others
Protein ID: NP_462910.3
Location: 4240105..4240416 (312 bp)
Type: Others
Protein ID: NP_462911.1
Location: 4240502..4241431 (930 bp)
Type: Others
Protein ID: NP_462912.1
Location: 4242298..4243227 (930 bp)
Type: Others
Protein ID: NP_462914.1
Location: 4243224..4243859 (636 bp)
Type: Others
Protein ID: NP_462915.1
Location: 4243856..4244758 (903 bp)
Type: Others
Protein ID: NP_462916.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
STM40264236762..4237361+600NP_462906.1putative enzyme-
STM40274237355..4238227+873NP_462907.1tRNA processing exoribonuclease BN-
STM40284238224..4238661+438NP_462908.1D-Tyr-tRNA(Tyr) deacylase-
STM40294238658..4239647+990NP_462909.1putative acetyltransferase-
STM40304239662..4240108-447NP_462910.3putative cytoplasmic protein-
STM40314240105..4240416-312NP_462911.1putative cytoplasmic protein-
STM40324240502..4241431-930NP_462912.1putative acetyl esterase-
-4241649..4241957+309--Toxin
STM40334241997..4242251+255NP_462913.3putative merR family bacterial regulatory proteinAntitoxin
STM40344242298..4243227-930NP_462914.1putative formate dehydrogenase formation protein-
STM40354243224..4243859-636NP_462915.1formate dehydrogenase, cytochrome B556 (FDO) subunit-
STM40364243856..4244758-903NP_462916.1formate dehydrogenase-O, Fe-S subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(24-73)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T6088 WP_001159630.1 NC_003197:4241649-4241957 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 309 bp

>T6088 NC_003197:4241649-4241957 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 10.7969

>AT6088 NP_462913.3 NC_003197:4241997-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALLRAIANDPRNVIQ
ALRY

Download         Length: 255 bp

>AT6088 NC_003197:4241997-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTCTCGTACCTTTCATATTGATGCAATGAAGATTAAAGA
AATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGCTGATTTCGGTCAACGTGGATACGCTGCGCAACTGGG
AGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTTCGCGCCATTGCCAACGACCCGAGAAACGTTATACAA
GCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T303Pseudomonas putida KT2440

56.311

100

0.563

T174Vibrio cholerae O1 biovar El Tor str. N16961

40.594

98.058

0.398
Showing 1 to 2 of 2 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT303Pseudomonas putida KT2440

65.854

97.619

0.643
Showing 1 to 1 of 1 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0R9NS64

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Miguel A De la Cruz et al. (2013) A toxin-antitoxin module of Salmonella promotes virulence in mice. PLoS Pathogens 9(12):e1003827. [PubMed:24385907] experimental


experimental experimental literature