49823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2373600..2374306 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name mqsR Uniprot ID Q9PAL4
Locus tag XFUD_RS11545 Protein ID WP_010894925.1
Coordinates 2373600..2373902 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q9PAL3
Locus tag XFUD_RS11550 Protein ID WP_010894926.1
Coordinates 2373905..2374306 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS11520 2368758..2369936 - 1179 WP_042462912.1 phage tail sheath family protein -
XFUD_RS11525 2370001..2371593 - 1593 WP_010894924.1 tail fiber domain-containing protein -
XFUD_RS11530 2371601..2372158 - 558 WP_010893249.1 phage tail protein I -
XFUD_RS11535 2372151..2373044 - 894 WP_010893248.1 baseplate J/gp47 family protein -
XFUD_RS11540 2373044..2373382 - 339 WP_042462908.1 GPW/gp25 family protein -
XFUD_RS11545 2373600..2373902 + 303 WP_010894925.1 type II toxin-antitoxin system MqsR family toxin Toxin
XFUD_RS11550 2373905..2374306 + 402 WP_010894926.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
XFUD_RS11555 2374375..2374962 - 588 WP_010894927.1 phage baseplate assembly protein V -
XFUD_RS11560 2374959..2375501 - 543 WP_010894928.1 hypothetical protein -
XFUD_RS11565 2375477..2375998 - 522 WP_010893241.1 hypothetical protein -
XFUD_RS11570 2375995..2376318 - 324 WP_042462902.1 hypothetical protein -
XFUD_RS11575 2376318..2376578 - 261 WP_010893239.1 hypothetical protein -
XFUD_RS11580 2376596..2378476 - 1881 WP_010893238.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2363203..2406302 43099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10958.74 Da        Isoelectric Point: 8.0251

>T49823 WP_010894925.1 NZ_CP009790:2373600-2373902 [Xylella fastidiosa]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Download         Length: 303 bp

>T49823 NZ_CP009790:2373600-2373902 [Xylella fastidiosa]
ATGGAGAAAGGCACACCCCACTACAAGCTACCAGTCGTCAAAGCCTTGGTAAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTTGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 15018.15 Da        Isoelectric Point: 7.1650

>AT49823 WP_010894926.1 NZ_CP009790:2373905-2374306 [Xylella fastidiosa]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKIRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSF

Download         Length: 402 bp

>AT49823 NZ_CP009790:2373905-2374306 [Xylella fastidiosa]
ATGAGATGTCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTATAAGAGCGAAACTAC
TAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCGTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTGGTCGGCTTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGATACGCCGGAAG
CTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAACGGTAAAAC
CAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTTTCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9PAL4

Antitoxin

Source ID Structure
AlphaFold DB Q9PAL3

References