Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1540186..1540778 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name PumA Uniprot ID Q9PD07
Locus tag XFUD_RS07255 Protein ID WP_010894094.1
Coordinates 1540482..1540778 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag XFUD_RS07250 Protein ID WP_004085592.1
Coordinates 1540186..1540479 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS07205 1535809..1536057 + 249 WP_042463681.1 hypothetical protein -
XFUD_RS07210 1535942..1536294 - 353 Protein_1295 antitoxin -
XFUD_RS07215 1536433..1536861 - 429 WP_010894086.1 type II toxin-antitoxin system VapC family toxin -
XFUD_RS07220 1536862..1537116 - 255 WP_042463183.1 plasmid stabilization protein -
XFUD_RS07225 1537228..1537998 + 771 WP_010894088.1 hypothetical protein -
XFUD_RS07230 1537998..1538315 + 318 WP_010894089.1 hypothetical protein -
XFUD_RS07235 1538312..1539142 + 831 WP_010894090.1 hypothetical protein -
XFUD_RS07240 1539139..1539780 + 642 WP_010894091.1 hypothetical protein -
XFUD_RS07245 1539777..1540130 + 354 WP_010894092.1 hypothetical protein -
XFUD_RS07250 1540186..1540479 - 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
XFUD_RS07255 1540482..1540778 - 297 WP_010894094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFUD_RS07260 1540970..1541189 + 220 Protein_1305 tail fiber protein -
XFUD_RS07265 1541379..1541825 - 447 WP_031336674.1 hypothetical protein -
XFUD_RS07270 1542067..1543044 - 978 WP_010894098.1 hypothetical protein -
XFUD_RS07275 1543041..1543916 - 876 WP_023906641.1 ABC transporter ATP-binding protein -
XFUD_RS13710 1544135..1544296 + 162 WP_010894100.1 hypothetical protein -
XFUD_RS07280 1544755..1545246 + 492 WP_171817079.1 glutathione peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1514336..1540778 26442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11167.73 Da        Isoelectric Point: 9.8173

>T49814 WP_010894094.1 NZ_CP009790:c1540778-1540482 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Download         Length: 297 bp

>T49814 NZ_CP009790:c1540778-1540482 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT49814 WP_004085592.1 NZ_CP009790:c1540479-1540186 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp

>AT49814 NZ_CP009790:c1540479-1540186 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTAGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S0V711

Antitoxin

Source ID Structure

References