Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 1535977..1536873 | Replicon | chromosome |
| Accession | NC_002488 | ||
| Organism | Xylella fastidiosa 9a5c | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q9PD15 |
| Locus tag | XF_RS06745 | Protein ID | WP_010894086.1 |
| Coordinates | 1536445..1536873 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | XF_RS13285 | Protein ID | WP_209319998.1 |
| Coordinates | 1535977..1536321 (-) | Length | 115 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XF_RS06720 (XF1583) | 1531095..1532591 | + | 1497 | WP_010894080.1 | DUF3383 domain-containing protein | - |
| XF_RS06725 (XF1584) | 1532601..1533038 | + | 438 | WP_010894081.1 | DUF3277 family protein | - |
| XF_RS06730 (XF1585) | 1533035..1533457 | + | 423 | WP_010894082.1 | hypothetical protein | - |
| XF_RS06735 (XF1587) | 1533605..1535494 | + | 1890 | WP_010894084.1 | hypothetical protein | - |
| XF_RS06740 | 1535821..1536069 | + | 249 | WP_042463681.1 | hypothetical protein | - |
| XF_RS13285 (XF1588) | 1535977..1536321 | - | 345 | WP_209319998.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| XF_RS06745 (XF1589) | 1536445..1536873 | - | 429 | WP_010894086.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| XF_RS06750 (XF1590) | 1536874..1537128 | - | 255 | WP_042463183.1 | plasmid stabilization protein | - |
| XF_RS06755 (XF1591) | 1537240..1538010 | + | 771 | WP_010894088.1 | hypothetical protein | - |
| XF_RS06760 (XF1592) | 1538010..1538327 | + | 318 | WP_010894089.1 | hypothetical protein | - |
| XF_RS06765 (XF1593) | 1538324..1539154 | + | 831 | WP_010894090.1 | hypothetical protein | - |
| XF_RS06770 (XF1594) | 1539151..1539792 | + | 642 | WP_010894091.1 | hypothetical protein | - |
| XF_RS06775 (XF1595) | 1539789..1540142 | + | 354 | WP_010894092.1 | hypothetical protein | - |
| XF_RS06780 (XF1596) | 1540198..1540491 | - | 294 | WP_004085592.1 | putative addiction module antidote protein | - |
| XF_RS06785 (XF1597) | 1540494..1540790 | - | 297 | WP_010894094.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| XF_RS06790 (XF1599) | 1540982..1541201 | + | 220 | Protein_1323 | tail fiber protein | - |
| XF_RS06795 (XF1600) | 1541391..1541837 | - | 447 | WP_031336674.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 1514347..1540790 | 26443 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15613.78 Da Isoelectric Point: 5.8629
>T20277 WP_010894086.1 NC_002488:c1536873-1536445 [Xylella fastidiosa 9a5c]
MIVLDTNVVSEAMKPEPDAAVRTWLNEQMSVTLYLSSVTLSELLFGIAVLPTSKRKDMLARTLDGLLDLFNERVLPFNTD
AARHYAELAVKARNSGRGFPTPDGYIAAIAASRGYIVASRDTSAYESSGVQVINPWQYSKQT
MIVLDTNVVSEAMKPEPDAAVRTWLNEQMSVTLYLSSVTLSELLFGIAVLPTSKRKDMLARTLDGLLDLFNERVLPFNTD
AARHYAELAVKARNSGRGFPTPDGYIAAIAASRGYIVASRDTSAYESSGVQVINPWQYSKQT
Download Length: 429 bp
>T20277 NC_002488:c1536873-1536445 [Xylella fastidiosa 9a5c]
ATGATTGTCTTGGATACCAATGTTGTTTCCGAAGCAATGAAACCCGAACCGGATGCAGCAGTCCGAACCTGGCTCAACGA
GCAGATGAGCGTCACGTTGTACCTATCCAGTGTGACGTTATCTGAACTGTTGTTTGGAATCGCAGTGTTGCCCACAAGTA
AACGCAAGGACATGTTGGCTCGAACCCTTGATGGCTTGCTTGATCTGTTCAATGAACGGGTGTTGCCGTTCAATACGGAC
GCGGCACGCCACTATGCCGAACTGGCAGTGAAAGCGAGAAACAGCGGGCGCGGCTTCCCCACACCGGATGGCTATATCGC
GGCAATTGCTGCATCACGAGGTTACATAGTGGCTTCCCGCGACACCTCAGCCTATGAGTCAAGTGGTGTGCAAGTCATCA
ATCCGTGGCAATACAGCAAACAAACATAG
ATGATTGTCTTGGATACCAATGTTGTTTCCGAAGCAATGAAACCCGAACCGGATGCAGCAGTCCGAACCTGGCTCAACGA
GCAGATGAGCGTCACGTTGTACCTATCCAGTGTGACGTTATCTGAACTGTTGTTTGGAATCGCAGTGTTGCCCACAAGTA
AACGCAAGGACATGTTGGCTCGAACCCTTGATGGCTTGCTTGATCTGTTCAATGAACGGGTGTTGCCGTTCAATACGGAC
GCGGCACGCCACTATGCCGAACTGGCAGTGAAAGCGAGAAACAGCGGGCGCGGCTTCCCCACACCGGATGGCTATATCGC
GGCAATTGCTGCATCACGAGGTTACATAGTGGCTTCCCGCGACACCTCAGCCTATGAGTCAAGTGGTGTGCAAGTCATCA
ATCCGTGGCAATACAGCAAACAAACATAG
Antitoxin
Download Length: 115 a.a. Molecular weight: 12885.07 Da Isoelectric Point: 10.5273
>AT20277 WP_209319998.1 NC_002488:c1536321-1535977 [Xylella fastidiosa 9a5c]
MGTVPMPISSPSSRTKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPITRPTNYCQVTEPVAKKHHSAQMIN
SIPYSRPMHGYIMNCWVVRVGWCRMGVSIIPGSN
MGTVPMPISSPSSRTKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPITRPTNYCQVTEPVAKKHHSAQMIN
SIPYSRPMHGYIMNCWVVRVGWCRMGVSIIPGSN
Download Length: 345 bp
>AT20277 NC_002488:c1536321-1535977 [Xylella fastidiosa 9a5c]
ATGGGTACCGTGCCAATGCCAATTTCATCTCCGTCATCACGTACCAAGGAAGCGAAGCTATTCCGAAATAATCGTAGCCA
GGCGGTACGAATTCCCGTTGAATTCGAGTTGCCGGGCGATCGTGTTCTGATCCACCGTGAGGGGAGCAAACTCATTATTG
AGCCGATCACCCGGCCAACCAACTATTGTCAAGTTACTGAACCAGTGGCTAAGAAGCACCACTCGGCCCAGATGATCAAT
TCCATTCCATATTCACGACCCATGCATGGCTATATTATGAATTGTTGGGTAGTAAGGGTGGGTTGGTGTCGGATGGGAGT
CTCCATAATTCCAGGCTCCAATTAA
ATGGGTACCGTGCCAATGCCAATTTCATCTCCGTCATCACGTACCAAGGAAGCGAAGCTATTCCGAAATAATCGTAGCCA
GGCGGTACGAATTCCCGTTGAATTCGAGTTGCCGGGCGATCGTGTTCTGATCCACCGTGAGGGGAGCAAACTCATTATTG
AGCCGATCACCCGGCCAACCAACTATTGTCAAGTTACTGAACCAGTGGCTAAGAAGCACCACTCGGCCCAGATGATCAAT
TCCATTCCATATTCACGACCCATGCATGGCTATATTATGAATTGTTGGGTAGTAAGGGTGGGTTGGTGTCGGATGGGAGT
CTCCATAATTCCAGGCTCCAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|