Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1536433..1537116 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name vapC Uniprot ID Q9PD15
Locus tag XFUD_RS07215 Protein ID WP_010894086.1
Coordinates 1536433..1536861 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag XFUD_RS07220 Protein ID WP_042463183.1
Coordinates 1536862..1537116 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS07190 1532589..1533026 + 438 WP_010894081.1 DUF3277 family protein -
XFUD_RS07195 1533023..1533445 + 423 WP_010894082.1 hypothetical protein -
XFUD_RS07200 1533593..1535482 + 1890 WP_010894084.1 hypothetical protein -
XFUD_RS07205 1535809..1536057 + 249 WP_042463681.1 hypothetical protein -
XFUD_RS07210 1535942..1536294 - 353 Protein_1295 antitoxin -
XFUD_RS07215 1536433..1536861 - 429 WP_010894086.1 type II toxin-antitoxin system VapC family toxin Toxin
XFUD_RS07220 1536862..1537116 - 255 WP_042463183.1 plasmid stabilization protein Antitoxin
XFUD_RS07225 1537228..1537998 + 771 WP_010894088.1 hypothetical protein -
XFUD_RS07230 1537998..1538315 + 318 WP_010894089.1 hypothetical protein -
XFUD_RS07235 1538312..1539142 + 831 WP_010894090.1 hypothetical protein -
XFUD_RS07240 1539139..1539780 + 642 WP_010894091.1 hypothetical protein -
XFUD_RS07245 1539777..1540130 + 354 WP_010894092.1 hypothetical protein -
XFUD_RS07250 1540186..1540479 - 294 WP_004085592.1 putative addiction module antidote protein -
XFUD_RS07255 1540482..1540778 - 297 WP_010894094.1 type II toxin-antitoxin system RelE/ParE family toxin -
XFUD_RS07260 1540970..1541189 + 220 Protein_1305 tail fiber protein -
XFUD_RS07265 1541379..1541825 - 447 WP_031336674.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1514336..1540778 26442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15613.78 Da        Isoelectric Point: 5.8629

>T49813 WP_010894086.1 NZ_CP009790:c1536861-1536433 [Xylella fastidiosa]
MIVLDTNVVSEAMKPEPDAAVRTWLNEQMSVTLYLSSVTLSELLFGIAVLPTSKRKDMLARTLDGLLDLFNERVLPFNTD
AARHYAELAVKARNSGRGFPTPDGYIAAIAASRGYIVASRDTSAYESSGVQVINPWQYSKQT

Download         Length: 429 bp

>T49813 NZ_CP009790:c1536861-1536433 [Xylella fastidiosa]
ATGATTGTCTTGGATACCAATGTTGTTTCCGAAGCAATGAAACCCGAACCGGATGCAGCAGTCCGAACCTGGCTCAACGA
GCAGATGAGCGTCACGTTGTACCTATCCAGTGTGACGTTATCTGAACTGTTGTTTGGAATCGCAGTGTTGCCCACAAGTA
AACGCAAGGACATGTTGGCTCGAACCCTTGATGGCTTGCTTGATCTGTTCAATGAACGGGTGTTGCCGTTCAATACGGAC
GCGGCACGCCACTATGCCGAACTGGCAGTGAAAGCGAGAAACAGCGGGCGCGGCTTCCCCACACCGGATGGCTATATCGC
GGCAATTGCTGCATCACGAGGTTACATAGTGGCTTCCCGCGACACCTCAGCCTATGAGTCAAGTGGTGTGCAAGTCATCA
ATCCGTGGCAATACAGCAAACAAACATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9607.93 Da        Isoelectric Point: 6.4732

>AT49813 WP_042463183.1 NZ_CP009790:c1537116-1536862 [Xylella fastidiosa]
MAMLTVRNLPDEVHRALRVRAATHGRSTEAEVREILTNMVKPDERVRIGDALATLGREIGLNNEDFTTFDKVRDKTQAEP
MRFE

Download         Length: 255 bp

>AT49813 NZ_CP009790:c1537116-1536862 [Xylella fastidiosa]
ATGGCCATGTTGACAGTGCGTAATTTGCCTGATGAAGTCCATCGAGCCTTGCGGGTTCGAGCCGCCACACACGGCCGCAG
TACAGAAGCAGAAGTACGTGAGATTTTAACGAACATGGTCAAGCCAGATGAGCGTGTTCGCATTGGCGATGCCTTGGCTA
CCCTGGGACGCGAGATCGGACTAAATAACGAGGATTTCACGACCTTTGATAAGGTGCGAGATAAGACGCAGGCCGAGCCA
ATGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9PD15

Antitoxin

Source ID Structure

References