Detailed information of TA system TA020279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1540198..1540790
• Replicon: chromosome
• Accession: NC_002488
• Organism: Xylella fastidiosa 9a5c

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: Q9PD07
• Locus tag: XF_RS06785
• Protein ID: WP_010894094.1
• Coordinates: 1540494..1540790 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: XF_RS06780
• Protein ID: WP_004085592.1
• Coordinates: 1540198..1540491 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XF_RS06740	1535821..1536069	+	249	WP_042463681.1	hypothetical protein	-
XF_RS13285 (XF1588)	1535977..1536321	-	345	WP_209319998.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
XF_RS06745 (XF1589)	1536445..1536873	-	429	WP_010894086.1	type II toxin-antitoxin system VapC family toxin	-
XF_RS06750 (XF1590)	1536874..1537128	-	255	WP_042463183.1	plasmid stabilization protein	-
XF_RS06755 (XF1591)	1537240..1538010	+	771	WP_010894088.1	hypothetical protein	-
XF_RS06760 (XF1592)	1538010..1538327	+	318	WP_010894089.1	hypothetical protein	-
XF_RS06765 (XF1593)	1538324..1539154	+	831	WP_010894090.1	hypothetical protein	-
XF_RS06770 (XF1594)	1539151..1539792	+	642	WP_010894091.1	hypothetical protein	-
XF_RS06775 (XF1595)	1539789..1540142	+	354	WP_010894092.1	hypothetical protein	-
XF_RS06780 (XF1596)	1540198..1540491	-	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
XF_RS06785 (XF1597)	1540494..1540790	-	297	WP_010894094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XF_RS06790 (XF1599)	1540982..1541201	+	220	Protein_1323	tail fiber protein	-
XF_RS06795 (XF1600)	1541391..1541837	-	447	WP_031336674.1	hypothetical protein	-
XF_RS06800 (XF1601)	1542079..1543056	-	978	WP_010894098.1	hypothetical protein	-
XF_RS06805 (XF1602)	1543053..1543928	-	876	WP_023906641.1	ABC transporter ATP-binding protein	-
XF_RS14655	1544107..1544268	-	162	WP_155641627.1	hypothetical protein	-
XF_RS06810 (XF1604)	1544767..1545258	+	492	WP_171817079.1	glutathione peroxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP009790 Xylella fastidiosa strain U24d Prophage TA049813, TA049814 1514336..1540778 0	inside	Prophage	-	-	1514347..1540790	26443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.73 Da
• Isoelectric Point: 9.8173

>T20279 WP_010894094.1 NC_002488:c1540790-1540494 [Xylella fastidiosa 9a5c]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T20279 NC_002488:c1540790-1540494 [Xylella fastidiosa 9a5c]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT20279 WP_004085592.1 NC_002488:c1540491-1540198 [Xylella fastidiosa 9a5c]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT20279 NC_002488:c1540491-1540198 [Xylella fastidiosa 9a5c]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTAGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A1S0V711