Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 680056..680623 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name higB Uniprot ID A0A1L2B3Z4
Locus tag XFUD_RS03295 Protein ID WP_042463596.1
Coordinates 680342..680623 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag XFUD_RS03290 Protein ID WP_010893244.1
Coordinates 680056..680331 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS03260 675950..677830 + 1881 WP_010893238.1 phage major capsid protein -
XFUD_RS03265 677848..678108 + 261 WP_010893239.1 hypothetical protein -
XFUD_RS03270 678108..678431 + 324 WP_042462902.1 hypothetical protein -
XFUD_RS03275 678428..678949 + 522 WP_010893241.1 hypothetical protein -
XFUD_RS03280 678925..679467 + 543 WP_042462905.1 hypothetical protein -
XFUD_RS03285 679464..680051 + 588 WP_010893243.1 phage baseplate assembly protein V -
XFUD_RS03290 680056..680331 - 276 WP_010893244.1 HigA family addiction module antidote protein Antitoxin
XFUD_RS03295 680342..680623 - 282 WP_042463596.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFUD_RS03300 680831..681169 + 339 WP_042462908.1 GPW/gp25 family protein -
XFUD_RS03305 681169..682062 + 894 WP_010893248.1 baseplate J/gp47 family protein -
XFUD_RS03310 682055..682612 + 558 WP_010893249.1 phage tail protein I -
XFUD_RS03315 682620..684212 + 1593 WP_010894924.1 tail fiber domain-containing protein -
XFUD_RS03320 684277..685455 + 1179 WP_042462912.1 phage tail sheath family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 650664..716701 66037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10578.06 Da        Isoelectric Point: 9.8536

>T49812 WP_042463596.1 NZ_CP009790:c680623-680342 [Xylella fastidiosa]
VIKSFRHKGIQQFFLEGSTAGIQTKHAAKLRIQLTALESAKHPKDMNAPGWKLHSLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T49812 NZ_CP009790:c680623-680342 [Xylella fastidiosa]
GTGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCGAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCTAAGCACCCCAAAGATATGAATGCTCCAGGCTGGAAACTGC
ACTCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTAAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10056.68 Da        Isoelectric Point: 10.2184

>AT49812 WP_010893244.1 NZ_CP009790:c680331-680056 [Xylella fastidiosa]
MKRMHNPAHPGEVLREYLGDLTVTNAAAKLGVSRVALSRILNGANGISADMALRLEDALGTSAEMWVAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT49812 NZ_CP009790:c680331-680056 [Xylella fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGATCTCACTGTGACCAATGCGGC
TGCAAAGCTTGGCGTCAGCCGTGTCGCTTTGTCGCGTATTCTCAATGGTGCCAACGGCATCTCTGCCGATATGGCCCTAC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGTAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCCAGTCAG
CAGCCACGCCCGAAGATCACACGCCTTCATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2B3Z4

Antitoxin

Source ID Structure

References