Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 680065..680632 Replicon chromosome
Accession NC_002488
Organism Xylella fastidiosa 9a5c

Toxin (Protein)


Gene name higB Uniprot ID A0A1L2B3Z4
Locus tag XF_RS03050 Protein ID WP_042463596.1
Coordinates 680351..680632 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag XF_RS03045 Protein ID WP_010893244.1
Coordinates 680065..680340 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF_RS03015 (XF0714) 675959..677839 + 1881 WP_010893238.1 phage major capsid protein -
XF_RS03020 (XF0715) 677857..678117 + 261 WP_010893239.1 hypothetical protein -
XF_RS03025 (XF0716) 678117..678440 + 324 WP_042462902.1 hypothetical protein -
XF_RS03030 (XF0717) 678437..678958 + 522 WP_010893241.1 hypothetical protein -
XF_RS03035 (XF0718) 678934..679476 + 543 WP_042462905.1 hypothetical protein -
XF_RS03040 (XF0719) 679473..680060 + 588 WP_010893243.1 phage baseplate assembly protein V -
XF_RS03045 (XF0720) 680065..680340 - 276 WP_010893244.1 HigA family addiction module antidote protein Antitoxin
XF_RS03050 (XF0721) 680351..680632 - 282 WP_042463596.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XF_RS03055 (XF0723) 680840..681178 + 339 WP_042462908.1 GPW/gp25 family protein -
XF_RS03060 (XF0724) 681178..682071 + 894 WP_010893248.1 baseplate J/gp47 family protein -
XF_RS03065 (XF0725) 682064..682621 + 558 WP_010893249.1 phage tail protein I -
XF_RS03070 (XF0726) 682629..684220 + 1592 Protein_603 tail fiber domain-containing protein -
XF_RS03075 (XF0727) 684285..685463 + 1179 WP_042462912.1 phage tail sheath family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 650674..716711 66037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10578.06 Da        Isoelectric Point: 9.8536

>T20276 WP_042463596.1 NC_002488:c680632-680351 [Xylella fastidiosa 9a5c]
VIKSFRHKGIQQFFLEGSTAGIQTKHAAKLRIQLTALESAKHPKDMNAPGWKLHSLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T20276 NC_002488:c680632-680351 [Xylella fastidiosa 9a5c]
GTGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCGAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCTAAGCACCCCAAAGATATGAATGCTCCAGGCTGGAAACTGC
ACTCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTAAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10056.68 Da        Isoelectric Point: 10.2184

>AT20276 WP_010893244.1 NC_002488:c680340-680065 [Xylella fastidiosa 9a5c]
MKRMHNPAHPGEVLREYLGDLTVTNAAAKLGVSRVALSRILNGANGISADMALRLEDALGTSAEMWVAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT20276 NC_002488:c680340-680065 [Xylella fastidiosa 9a5c]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGATCTCACTGTGACCAATGCGGC
TGCAAAGCTTGGCGTCAGCCGTGTCGCTTTGTCGCGTATTCTCAATGGTGCCAACGGCATCTCTGCCGATATGGCCCTAC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGTAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCCAGTCAG
CAGCCACGCCCGAAGATCACACGCCTTCATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2B3Z4

Antitoxin

Source ID Structure

References