30325

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4574900..4575447 Replicon chromosome
Accession NC_022808
Organism Pseudomonas aeruginosa PA1

Toxin (Protein)


Gene name relE Uniprot ID A0A6A9K6G2
Locus tag PA1S_RS21305 Protein ID WP_023102603.1
Coordinates 4575172..4575447 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6A9LA76
Locus tag PA1S_RS21300 Protein ID WP_023102602.1
Coordinates 4574900..4575172 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA1S_RS30885 (PA1S_21295) 4571566..4572597 + 1032 WP_043487154.1 hypothetical protein -
PA1S_RS21290 (PA1S_21300) 4572608..4573273 + 666 WP_049859794.1 DUF3218 family protein -
PA1S_RS31505 4573695..4574030 + 336 WP_185832033.1 hypothetical protein -
PA1S_RS21295 (PA1S_21305) 4574087..4574647 - 561 WP_023102601.1 recombinase family protein -
PA1S_RS21300 (PA1S_21310) 4574900..4575172 + 273 WP_023102602.1 ribbon-helix-helix domain-containing protein Antitoxin
PA1S_RS21305 (PA1S_21315) 4575172..4575447 + 276 WP_023102603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PA1S_RS30900 4576547..4577407 - 861 WP_079279917.1 cytolethal distending toxin subunit B family protein -
PA1S_RS30905 4577424..4577960 - 537 WP_079279916.1 hypothetical protein -
PA1S_RS30910 4578282..4579010 - 729 WP_049859666.1 SDR family oxidoreductase -
PA1S_RS30915 4579645..4580283 + 639 WP_049859665.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 4518241..4621030 102789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10689.27 Da        Isoelectric Point: 9.9307

>T30325 WP_023102603.1 NC_022808:4575172-4575447 [Pseudomonas aeruginosa PA1]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T30325 NC_022808:4575172-4575447 [Pseudomonas aeruginosa PA1]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGGCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCCGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10087.34 Da        Isoelectric Point: 4.6413

>AT30325 WP_023102602.1 NC_022808:4574900-4575172 [Pseudomonas aeruginosa PA1]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDAGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT30325 NC_022808:4574900-4575172 [Pseudomonas aeruginosa PA1]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGCCGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9K6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9LA76

References