56950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4574901..4575448 Replicon chromosome
Accession NZ_CP012679
Organism Pseudomonas aeruginosa strain PA1RG

Toxin (Protein)


Gene name relE Uniprot ID A0A6A9K6G2
Locus tag AOD73_RS21295 Protein ID WP_023102603.1
Coordinates 4575173..4575448 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6A9LA76
Locus tag AOD73_RS21290 Protein ID WP_023102602.1
Coordinates 4574901..4575173 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOD73_RS30925 4571567..4572598 + 1032 WP_043487154.1 hypothetical protein -
AOD73_RS21280 4572609..4573274 + 666 WP_049859794.1 DUF3218 family protein -
AOD73_RS31560 4573696..4574031 + 336 WP_185832033.1 hypothetical protein -
AOD73_RS21285 4574088..4574648 - 561 WP_023102601.1 recombinase family protein -
AOD73_RS21290 4574901..4575173 + 273 WP_023102602.1 ribbon-helix-helix domain-containing protein Antitoxin
AOD73_RS21295 4575173..4575448 + 276 WP_023102603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOD73_RS30940 4576548..4577408 - 861 WP_079279917.1 cytolethal distending toxin subunit B family protein -
AOD73_RS30945 4577425..4577961 - 537 WP_079279916.1 hypothetical protein -
AOD73_RS30950 4578283..4579011 - 729 WP_049859666.1 SDR family oxidoreductase -
AOD73_RS30955 4579646..4580284 + 639 WP_049859665.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 4518241..4621031 102790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10689.27 Da        Isoelectric Point: 9.9307

>T56950 WP_023102603.1 NZ_CP012679:4575173-4575448 [Pseudomonas aeruginosa]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T56950 NZ_CP012679:4575173-4575448 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGGCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCCGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10087.34 Da        Isoelectric Point: 4.6413

>AT56950 WP_023102602.1 NZ_CP012679:4574901-4575173 [Pseudomonas aeruginosa]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDAGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT56950 NZ_CP012679:4574901-4575173 [Pseudomonas aeruginosa]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGCCGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9K6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9LA76

References