Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5067552..5068099 Replicon chromosome
Accession NC_022806
Organism Pseudomonas aeruginosa PA1R

Toxin (Protein)


Gene name relE Uniprot ID A0A6A9K6G2
Locus tag PA1R_RS23385 Protein ID WP_023102603.1
Coordinates 5067552..5067827 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6A9LA76
Locus tag PA1R_RS23390 Protein ID WP_023102602.1
Coordinates 5067827..5068099 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA1R_RS29355 5062716..5063354 - 639 WP_049859665.1 TetR/AcrR family transcriptional regulator -
PA1R_RS29360 5063989..5064717 + 729 WP_049859666.1 SDR family oxidoreductase -
PA1R_RS30145 5065039..5065575 + 537 WP_079279916.1 hypothetical protein -
PA1R_RS30150 5065592..5066452 + 861 WP_079279917.1 cytolethal distending toxin subunit B family protein -
PA1R_RS23385 5067552..5067827 - 276 WP_023102603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PA1R_RS23390 5067827..5068099 - 273 WP_023102602.1 ribbon-helix-helix domain-containing protein Antitoxin
PA1R_RS23395 5068352..5068912 + 561 WP_023102601.1 recombinase family protein -
PA1R_RS30680 5068969..5069304 - 336 WP_185832033.1 hypothetical protein -
PA1R_RS23400 5069726..5070391 - 666 WP_049859794.1 DUF3218 family protein -
PA1R_RS30165 5070402..5071433 - 1032 WP_043487154.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 5021959..5124759 102800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10689.27 Da        Isoelectric Point: 9.9307

>T30318 WP_023102603.1 NC_022806:c5067827-5067552 [Pseudomonas aeruginosa PA1R]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T30318 NC_022806:c5067827-5067552 [Pseudomonas aeruginosa PA1R]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGGCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCCGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10087.34 Da        Isoelectric Point: 4.6413

>AT30318 WP_023102602.1 NC_022806:c5068099-5067827 [Pseudomonas aeruginosa PA1R]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDAGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT30318 NC_022806:c5068099-5067827 [Pseudomonas aeruginosa PA1R]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGCCGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9K6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9LA76

References