293505

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3832905..3834223 Replicon chromosome
Accession NZ_LT827011
Organism Escherichia coli O127:H6 isolate EPEC E2348/69 variety

Toxin (Protein)


Gene name HipT Uniprot ID B7UL96
Locus tag BQ9544_RS20510 Protein ID WP_001262465.1
Coordinates 3832905..3833912 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID B7UL97
Locus tag BQ9544_RS20515 Protein ID WP_001346664.1
Coordinates 3833912..3834223 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9544_RS20465 3828075..3829754 + 1680 WP_000191555.1 cellulose biosynthesis protein BcsG -
BQ9544_RS20470 3829869..3830327 - 459 WP_000526113.1 IS200/IS605-like element IS200C family transposase -
BQ9544_RS20480 3830551..3830658 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 3830707..3830772 + 66 NuclAT_18 - -
- 3830707..3830772 + 66 NuclAT_18 - -
- 3830707..3830772 + 66 NuclAT_18 - -
- 3830707..3830772 + 66 NuclAT_18 - -
- 3830707..3830772 + 66 NuclAT_24 - -
- 3830707..3830772 + 66 NuclAT_24 - -
- 3830707..3830772 + 66 NuclAT_24 - -
- 3830707..3830772 + 66 NuclAT_24 - -
BQ9544_RS25850 3831034..3831141 - 108 WP_000170747.1 type I toxin-antitoxin system toxin Ldr family protein -
- 3831190..3831255 + 66 NuclAT_19 - -
- 3831190..3831255 + 66 NuclAT_19 - -
- 3831190..3831255 + 66 NuclAT_19 - -
- 3831190..3831255 + 66 NuclAT_19 - -
- 3831190..3831255 + 66 NuclAT_25 - -
- 3831190..3831255 + 66 NuclAT_25 - -
- 3831190..3831255 + 66 NuclAT_25 - -
- 3831190..3831255 + 66 NuclAT_25 - -
BQ9544_RS20505 3831617..3832888 + 1272 WP_001339917.1 amino acid permease -
BQ9544_RS20510 3832905..3833912 - 1008 WP_001262465.1 HipA domain-containing protein Toxin
BQ9544_RS20515 3833912..3834223 - 312 WP_001346664.1 HipA N-terminal domain-containing protein Antitoxin
BQ9544_RS20520 3834208..3834531 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
BQ9544_RS20525 3834756..3835769 - 1014 WP_000103582.1 dipeptide ABC transporter ATP-binding subunit DppF -
BQ9544_RS20530 3835766..3836749 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
BQ9544_RS20535 3836760..3837662 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
BQ9544_RS20540 3837672..3838691 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3829869..3830327 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-99)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38329.55 Da        Isoelectric Point: 5.4135

>T293505 WP_001262465.1 NZ_LT827011:c3833912-3832905 [Escherichia coli O127:H6]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLNPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11831.41 Da        Isoelectric Point: 6.3215

>AT293505 WP_001346664.1 NZ_LT827011:c3834223-3833912 [Escherichia coli O127:H6]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAHDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AB4
PDB 7AB5
PDB 7AB3

Antitoxin

Source ID Structure
PDB 7AB4
PDB 7AB5
PDB 7AB3
AlphaFold DB A0A0K5V9L6

References