Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid 2
Accession NZ_LR898869
Organism Escherichia coli isolate MSB1_1D-sc-2280324

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag JMX26_RS22005 Protein ID WP_000969996.1
Coordinates 2252..2533 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag JMX26_RS22000 Protein ID WP_000079928.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX26_RS21995 46..1077 + 1032 WP_000907874.1 replication initiation protein -
JMX26_RS22000 1986..2255 + 270 WP_000079928.1 hypothetical protein Antitoxin
JMX26_RS22005 2252..2533 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX26_RS22010 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
JMX26_RS22015 3538..4011 + 474 WP_001334658.1 hypothetical protein -
JMX26_RS22020 4754..5248 - 495 WP_023278058.1 hypothetical protein -
JMX26_RS22025 5304..5906 - 603 WP_000517689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..96021 96021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T292048 WP_000969996.1 NZ_LR898869:2252-2533 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT292048 WP_000079928.1 NZ_LR898869:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References