285407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2729496..2730163 Replicon chromosome
Accession NZ_LM993812
Organism Escherichia coli strain K-12 substr. HMS174

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag ECHMS174_RS13520 Protein ID WP_001094400.1
Coordinates 2729834..2730163 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag ECHMS174_RS13515 Protein ID WP_000072690.1
Coordinates 2729496..2729813 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHMS174_RS13495 2724548..2725557 - 1010 Protein_2579 arsenic transporter -
ECHMS174_RS13500 2725699..2727402 + 1704 WP_000896263.1 hypothetical protein -
ECHMS174_RS23890 2727974..2728197 + 224 Protein_2581 DUF905 family protein -
ECHMS174_RS13505 2728300..2728758 + 459 WP_000211841.1 antirestriction protein -
ECHMS174_RS13510 2728767..2729249 + 483 WP_001407480.1 RadC family protein -
ECHMS174_RS23895 2729258..2729458 + 201 WP_001395452.1 DUF987 domain-containing protein -
ECHMS174_RS13515 2729496..2729813 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECHMS174_RS13520 2729834..2730163 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
ECHMS174_RS22835 2730527..2735107 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2708540..2740619 32079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T285407 WP_001094400.1 NZ_LM993812:2729834-2730163 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT285407 WP_000072690.1 NZ_LM993812:2729496-2729813 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References