276721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 137830..138497 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QCG45_RS00675 Protein ID WP_001094400.1
Coordinates 137830..138159 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QCG45_RS00680 Protein ID WP_000072690.1
Coordinates 138180..138497 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS00670 (132886) 132886..137466 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
QCG45_RS00675 (137830) 137830..138159 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QCG45_RS00680 (138180) 138180..138497 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QCG45_RS00685 (138535) 138535..138735 - 201 WP_001395452.1 DUF987 domain-containing protein -
QCG45_RS00690 (138744) 138744..139226 - 483 WP_001407480.1 RadC family protein -
QCG45_RS00695 (139235) 139235..139693 - 459 WP_000211841.1 antirestriction protein -
QCG45_RS00700 (139796) 139796..139980 - 185 Protein_133 DUF905 family protein -
QCG45_RS00705 (140591) 140591..142294 - 1704 WP_000896263.1 protein YfjW -
QCG45_RS00710 (142436) 142436..143445 + 1010 Protein_135 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 128178..160058 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T276721 WP_001094400.1 NZ_CP122318:c138159-137830 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT276721 WP_000072690.1 NZ_CP122318:c138497-138180 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References