276659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 104416..105083 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QCG48_RS00540 Protein ID WP_001094400.1
Coordinates 104416..104745 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QCG48_RS00545 Protein ID WP_000072690.1
Coordinates 104766..105083 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS00535 (99472) 99472..104052 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
QCG48_RS00540 (104416) 104416..104745 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QCG48_RS00545 (104766) 104766..105083 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QCG48_RS00550 (105121) 105121..105321 - 201 WP_001395452.1 DUF987 domain-containing protein -
QCG48_RS00555 (105330) 105330..105812 - 483 WP_001407480.1 RadC family protein -
QCG48_RS00560 (105821) 105821..106279 - 459 WP_000211841.1 antirestriction protein -
QCG48_RS00565 (106382) 106382..106566 - 185 Protein_106 DUF905 family protein -
QCG48_RS00570 (107177) 107177..108880 - 1704 WP_000896263.1 protein YfjW -
QCG48_RS00575 (109022) 109022..110031 + 1010 Protein_108 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 94764..126644 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T276659 WP_001094400.1 NZ_CP122316:c104745-104416 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT276659 WP_000072690.1 NZ_CP122316:c105083-104766 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References