Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
Location | 104416..105083 | Replicon | chromosome |
Accession | NZ_CP122316 | ||
Organism | Escherichia coli strain HT-946 |
Toxin (Protein)
Gene name | ypjF | Uniprot ID | Q46953 |
Locus tag | QCG48_RS00540 | Protein ID | WP_001094400.1 |
Coordinates | 104416..104745 (-) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | yfjZ | Uniprot ID | P52141 |
Locus tag | QCG48_RS00545 | Protein ID | WP_000072690.1 |
Coordinates | 104766..105083 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QCG48_RS00535 (99472) | 99472..104052 | + | 4581 | WP_010723187.1 | adhesin-like autotransporter YpjA/EhaD | - |
QCG48_RS00540 (104416) | 104416..104745 | - | 330 | WP_001094400.1 | type IV toxin-antitoxin system toxin YpjF | Toxin |
QCG48_RS00545 (104766) | 104766..105083 | - | 318 | WP_000072690.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
QCG48_RS00550 (105121) | 105121..105321 | - | 201 | WP_001395452.1 | DUF987 domain-containing protein | - |
QCG48_RS00555 (105330) | 105330..105812 | - | 483 | WP_001407480.1 | RadC family protein | - |
QCG48_RS00560 (105821) | 105821..106279 | - | 459 | WP_000211841.1 | antirestriction protein | - |
QCG48_RS00565 (106382) | 106382..106566 | - | 185 | Protein_106 | DUF905 family protein | - |
QCG48_RS00570 (107177) | 107177..108880 | - | 1704 | WP_000896263.1 | protein YfjW | - |
QCG48_RS00575 (109022) | 109022..110031 | + | 1010 | Protein_108 | arsenic transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 94764..126644 | 31880 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12308.21 Da Isoelectric Point: 7.2761
>T276659 WP_001094400.1 NZ_CP122316:c104745-104416 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK
Download Length: 330 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A373F4I3 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 2EA9 | |
PDB | 2JN7 | |
AlphaFold DB | P52141 |