Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
Location | 1118880..1120317 | Replicon | chromosome |
Accession | NZ_CP117010 | ||
Organism | Escherichia coli strain MLI110 |
Toxin (Protein)
Gene name | rnlA | Uniprot ID | P52129 |
Locus tag | NL413_RS06120 | Protein ID | WP_000155570.1 |
Coordinates | 1119244..1120317 (-) | Length | 358 a.a. |
Antitoxin (Protein)
Gene name | rnlB | Uniprot ID | P52130 |
Locus tag | NL413_RS06115 | Protein ID | WP_000461704.1 |
Coordinates | 1118880..1119251 (-) | Length | 124 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL413_RS06090 (1115111) | 1115111..1115554 | - | 444 | WP_000824222.1 | lipoprotein YfjS | - |
NL413_RS06095 (1115554) | 1115554..1115790 | - | 237 | WP_001144029.1 | protein YpjK | - |
NL413_RS06100 (1115831) | 1115831..1116532 | - | 702 | WP_000189409.1 | WYL domain-containing protein | - |
NL413_RS06105 (1116749) | 1116749..1117570 | - | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
NL413_RS06110 (1117662) | 1117662..1118525 | - | 864 | WP_000787597.1 | GTPase family protein | - |
NL413_RS06115 (1118880) | 1118880..1119251 | - | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
NL413_RS06120 (1119244) | 1119244..1120317 | - | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
NL413_RS06125 (1120459) | 1120459..1120722 | + | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
NL413_RS06130 (1121082) | 1121082..1122698 | + | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
NL413_RS06135 (1122695) | 1122695..1124884 | + | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1095150..1130681 | 35531 | ||
- | inside | Prophage | - | luxS | 1051699..1130076 | 78377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T269793 WP_000155570.1 NZ_CP117010:c1120317-1119244 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT269793 WP_000461704.1 NZ_CP117010:c1119251-1118880 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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