267029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2233530..2234197 Replicon chromosome
Accession NZ_CP114896
Organism Escherichia coli strain CM93

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6117_RS11000 Protein ID WP_001094400.1
Coordinates 2233868..2234197 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6117_RS10995 Protein ID WP_000072690.1
Coordinates 2233530..2233847 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6117_RS10965 (2228582) 2228582..2229591 - 1010 Protein_2140 arsenic transporter -
O6117_RS10970 (2229733) 2229733..2231436 + 1704 WP_000896263.1 protein YfjW -
O6117_RS10975 (2232047) 2232047..2232231 + 185 Protein_2142 DUF905 family protein -
O6117_RS10980 (2232334) 2232334..2232792 + 459 WP_000211841.1 antirestriction protein -
O6117_RS10985 (2232801) 2232801..2233283 + 483 WP_001407480.1 RadC family protein -
O6117_RS10990 (2233292) 2233292..2233492 + 201 WP_001395452.1 DUF987 domain-containing protein -
O6117_RS10995 (2233530) 2233530..2233847 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6117_RS11000 (2233868) 2233868..2234197 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6117_RS11005 (2234561) 2234561..2239141 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2212574..2254459 41885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T267029 WP_001094400.1 NZ_CP114896:2233868-2234197 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT267029 WP_000072690.1 NZ_CP114896:2233530-2233847 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References