266953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2338164..2338831 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag O6R07_RS11400 Protein ID WP_001094400.1
Coordinates 2338164..2338493 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag O6R07_RS11405 Protein ID WP_000072690.1
Coordinates 2338514..2338831 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS11395 (2333220) 2333220..2337800 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
O6R07_RS11400 (2338164) 2338164..2338493 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
O6R07_RS11405 (2338514) 2338514..2338831 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
O6R07_RS11410 (2338869) 2338869..2339069 - 201 WP_001395452.1 DUF987 domain-containing protein -
O6R07_RS11415 (2339078) 2339078..2339560 - 483 WP_001407480.1 RadC family protein -
O6R07_RS11420 (2339569) 2339569..2340027 - 459 WP_000211841.1 antirestriction protein -
O6R07_RS11425 (2340130) 2340130..2340353 - 224 Protein_2214 DUF905 family protein -
O6R07_RS11430 (2340925) 2340925..2342628 - 1704 WP_000896263.1 protein YfjW -
O6R07_RS11435 (2342770) 2342770..2343779 + 1010 Protein_2216 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2323387..2360392 37005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T266953 WP_001094400.1 NZ_CP114893:c2338493-2338164 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT266953 WP_000072690.1 NZ_CP114893:c2338831-2338514 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References