264719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 964296..964963 Replicon chromosome
Accession NZ_CP110999
Organism Escherichia coli strain J53-p133

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag ORI88_RS04695 Protein ID WP_001094400.1
Coordinates 964296..964625 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag ORI88_RS04700 Protein ID WP_000072690.1
Coordinates 964646..964963 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI88_RS04690 (959352) 959352..963932 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
ORI88_RS04695 (964296) 964296..964625 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
ORI88_RS04700 (964646) 964646..964963 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ORI88_RS04705 (965001) 965001..965201 - 201 WP_001395452.1 DUF987 domain-containing protein -
ORI88_RS04710 (965210) 965210..965692 - 483 WP_001407480.1 RadC family protein -
ORI88_RS04715 (965701) 965701..966159 - 459 WP_000211841.1 antirestriction protein -
ORI88_RS04720 (966262) 966262..966446 - 185 Protein_919 DUF905 family protein -
ORI88_RS04725 (967057) 967057..968760 - 1704 WP_000896263.1 protein YfjW -
ORI88_RS04730 (968902) 968902..969911 + 1010 Protein_921 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 953306..986524 33218
- flank IS/Tn - - 958097..959305 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T264719 WP_001094400.1 NZ_CP110999:c964625-964296 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT264719 WP_000072690.1 NZ_CP110999:c964963-964646 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References