Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1111548..1112215 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag OQ464_RS05345 Protein ID WP_001094400.1
Coordinates 1111548..1111877 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag OQ464_RS05350 Protein ID WP_000072690.1
Coordinates 1111898..1112215 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS05340 (1106604) 1106604..1111184 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
OQ464_RS05345 (1111548) 1111548..1111877 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
OQ464_RS05350 (1111898) 1111898..1112215 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OQ464_RS05355 (1112253) 1112253..1112453 - 201 WP_001395452.1 DUF987 domain-containing protein -
OQ464_RS05360 (1112462) 1112462..1112944 - 483 WP_001407480.1 RadC family protein -
OQ464_RS05365 (1112953) 1112953..1113411 - 459 WP_000211841.1 antirestriction protein -
OQ464_RS05370 (1113514) 1113514..1113698 - 185 Protein_1050 DUF905 family protein -
OQ464_RS05375 (1114309) 1114309..1116012 - 1704 WP_000896263.1 protein YfjW -
OQ464_RS05380 (1116154) 1116154..1117163 + 1010 Protein_1052 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1101896..1133776 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T264391 WP_001094400.1 NZ_CP110859:c1111877-1111548 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT264391 WP_000072690.1 NZ_CP110859:c1112215-1111898 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References