263715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 490099..490652 Replicon chromosome
Accession NZ_CP110362
Organism Dickeya dadantii strain XJ12

Toxin (Protein)


Gene name ccdB Uniprot ID E0SJL3
Locus tag OL445_RS02295 Protein ID WP_013318624.1
Coordinates 490099..490413 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID E0SJL4
Locus tag OL445_RS02300 Protein ID WP_013318625.1
Coordinates 490416..490652 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OL445_RS02285 489539..489832 + 294 Protein_447 integrase -
OL445_RS02290 489830..490102 + 273 Protein_448 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
OL445_RS02295 490099..490413 - 315 WP_013318624.1 CcdB family protein Toxin
OL445_RS02300 490416..490652 - 237 WP_013318625.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OL445_RS02305 490967..491911 - 945 WP_033111950.1 zincin-like metallopeptidase domain-containing protein -
OL445_RS02310 492626..493945 + 1320 Protein_452 TerB N-terminal domain-containing protein -
OL445_RS02315 493933..494358 + 426 Protein_453 DEAD/DEAH box helicase -
OL445_RS02320 494441..494569 - 129 WP_284603348.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - vgrG2 / hcp 427843..502453 74610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11564.48 Da        Isoelectric Point: 7.9859

>T263715 WP_013318624.1 NZ_CP110362:c490413-490099 [Dickeya dadantii]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERFVPVVRLTDGKEYAVMTHELASIPVQALG
TVFCDASQYRNQIKAAIDFLIDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9017.02 Da        Isoelectric Point: 6.4792

>AT263715 WP_013318625.1 NZ_CP110362:c490652-490416 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRHHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SJL3

Antitoxin

Source ID Structure
AlphaFold DB E0SJL4

References